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Received August 20, 1999. Revision received October 6, 1999. Accepted October 18, 1999. Address all correspondence and requests for reprints to: Th. C. J. Sas, M.D., Sophia Children's Hospital, Department of Pediatrics, Division of Endocrinology, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands. * This work was supported by Novo Nordisk A S Bagsvaerd, Denmark ; . A 4-yr analysis has been published in Metabolism 1999. The participating members of the Dutch Advisory Group on Growth Hormone were: Thom Vulsma, Emma Children's Hospital, Academic Medical Center Amsterdam Gera Hoorweg-Nijman, Free University Hospital Amsterdam Cathrienus Rouwe, Beatrix Chil dren's Hospital Groningen Guy Massa, Medical University Center Leiden Jos Gosen, Rijnland Hospital Leiderdorp Willem-Jan Gerver, Academic Hospital Maastricht Bartho Otten, Sint Radboud University Hospital Nijmegen Ciska Rongen-Westerlaken, Canisius-Wilhelmina Hospital Nijmegen Sabine de Muinck Keizer-Schrama, Stenvert Drop, Sophia Children's Hospital Rotterdam Maarten Reeser, Juliana Children's Hospital The Hague and Maarten Jansen, Wilhelmina Children's Hospital Utrecht.
Each gram of Topicort Gel 0.05% contains 0.5 mg of desoximetasone in a gel base consisting of purified water, docusate sodium, edetate disodium, isopropyl myristate, carbomer 940, trolamine, and SDAG-3 95% alcohol. Each gram of Topicort Ointment 0.25% contains 2.5 mg of desoximetasone in an ointment base consisting of white petrolatum and fractionated coconut oil.
ZLB Plasma Services is a division of ZLB Behring, one of the world's leading pharmaceutical companies specializing in the manufacture of plasma-derived products. ZLB Behring is headquartered in King of Prussia, Pennsylvania and operates three manufacturing facilities located in Kankakee, Illinois; Marburg, Germany; and Bern, Switzerland. ZLB Behring is a.
The timing of my back pain seemed to correlate almost exactly with my hemoglobin dropping low and my needing a transfusion. One constant factor I noticed, was I had back pain when I was about to receive a transfusion. Another constant I recognized was that during and just following my transfusion, I experienced more frequent bowel movements. I enabled myself to solve my back pain by being armed with better information regarding my condition. The results from my personal study showed that medication had no effect; but diet, exercise, and transfusions played a factor in my back pain. Foods difficult to digest, such as onions, increased the back pain. Exercise or stress raised my blood pressure causing the pain to be more aggressive. Finally, transfusions were the key. Low hemoglobin was the determining factor to my back pain. Diet and exercise only affected already existing pain caused by low hemoglobin. The pain comes from as simple a thing as gas, and simple pains can be cured easily. What happens is gas becomes trapped in the colon due to constipation caused by insufficient blood necessary to digest food properly. The condition of constipation can be easily solved. I happy to report I have not had back pain since my discovery; this cure may also work for your own back pain. At the first hint of back pain, or when it is close to my transfusion, I take one or two capsules of 100mg. Docusate Sodium, available over-the-counter at any pharmacy and many stores. As soon as I receive my transfusion, I discontinue use until it's time for my next transfusion. Let me know what you have experienced.
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The following groups are recommended to receive annual influenza vaccination . Persons at Increased Risk for Complications . adults and children who have required regular medical follow-up or hospitalization during the preceding year because of chronic metabolic diseases including diabetes mellitus ; , renal dysfunction, hemoglobinopathies, or immunosuppression including immunosuppression caused by medications or by human immunodeficiency virus [HIV] ; ."9 3.
Topicort Gel: Each tube contains: desoximetasone, 0.05%. Nonmedicinal ingredients: alcohol, carbopol 940 carboxypolymethylene ; , docusate sodium, edetate disodium, isopropyl myristate, trolamine and water. Extended-tip tubes of 20 and 60 g. Topicort Ointment: Each tube contains: desoximetasone, 0.25%. Nonmedicinal ingredients: aluminum stearate, beeswax, butylated hydroxyanisole, citric acid, fatty acid pentaerythritol ester, fatty alcohol citrate, propylene glycol, sorbitan sesquioleate and white petrolatum. Tubes of 20 and 60 g and dofetilide.
Introduction Dr Virginia Murray, Division of Chemical Hazards and Poisons London ; , Health Protection Agency Exercising and scenario playing are considered by the Health Protection Agency to be essential activities to test plans and prepare for a co-ordinated response in the event of a real HAZMAT hazardous materials ; or CBRN chemical, biological, radiological or nuclear ; incident. This Chemical Incident Report summarises two recent exercises where our service has played a part in the process. The first report comes from Exercise Black Knight. This exercise had over 3, 000 players and lasted for 50 hours. For this exercise we have included five reports: a summary of the scenario, a report from the activities at Silver, the plans and process used at Health Gold Chemical Incident Response Service perspective Dstl, Defence Science and Technology Laboratories, Porton Down The second report is from a recent exercise at the Emergency Department at the John Radcliffe Hospital, Oxford. A detailed report of the lessons learned for this department and hospital has been included.
Patients were considered eligible for the study if the following criteria were met. Histologically proven diagnosis of melanoma with distant metastases stage IV ; , with at least one bidimensionally measurable lesion according to WHO criteria, Eastern Cooperative Oncology Group ECOG ; performance status 2. Patients could not have received prior chemotherapy or immunotherapy for metastatic disease. Neo-adjuvant therapy and experimental vaccine treatment were allowed. Patients had adequate haematological function, haemoglobin 10 g dl, neutrophils 1.5 109 l and dok.
Oligodendrocyte mitochondria convert cholesterol to pregnenolone. Proc Natl Acad Sci USA 84: 8215 8219. Izenwasser S, Thompson-Montgomery DT, Deben SE, Chowdhury IN, and Werling LL 1998 ; Modulation of amphetamine-stimulated transporter-mediated ; dopamine release by sigma2 receptor agonists and antagonists in vitro. Eur J Pharmacol 346: 189 196. Jung-Testas Z, Hu ZY, Baulieu EE, and Robel P 1989 ; Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. Endocrinology 125: 20832091. Klein M and Musacchio JM 1994 ; Effects of cytochrome P-450 ligands on the binding of [3H]dextromethorphan and sigma ligands on to guinea pig brain, in Sigma Receptors Itzhak Y ed ; pp 243262, Academic Press, San Diego. Liu X, Nuwayhid S, Christie M, Kassiou M, and Werling LL 2001 ; Trishmocubanes: novel ligands modulate amphetamine-stimulated [3H]dopamine release. Eur J Pharmacol 422: 39 45. Marino PJ, Pallottini V, and Trentalance A 1998 ; Estrogens cause rapid activation of IP3-PKC signal transduction in HEPG2 cells. Biochem Biophys Res Commun 245: 254 258. Martin WR, Eades CG, Thompson JA, Huppler RE, and Gilbert PE 1976 ; The effects of morphine- and nalorphine-type drugs in the non-dependent and morphinedependent chronic spinal dog. J Pharmacol Exp Ther 197: 517532. Maurice T, Phan VL, Urani A, and Guillemain 2001 ; Differential involvement of the sigma-1 receptor in the anti-amnesic effect of neuroactive steroids as demonstrated using an antisense oligonucleotide strategy in the mouse. Br J Pharmacol 134: 17311741. Maurice T, Phan VL, Urani A, Kamei H, Noda Y, and Nabeshima T 1999 ; Neuroactive steroids as endogenous effectors for the sigma1 1 ; receptor: pharmacological evidence and therapeutic opportunities. Jpn J Pharmacol 81: 125155. McCann DM and Su TP 1994 ; Sigma1 and sigma2 sites in rat brain: comparison of regional, ontogenetic and subcellular patterns. Synapse 17: 182189. Meyer DA, Carta M, Partridge D, Covey DF, and Valenzuela CF 2002 ; Neurosteroids enhance spontaneous glutamate release in hippocampal neurons: possible role of metabotropic 1 like receptors. J Biol Chem 277: 2872528732. Moltzen EK, Perregard TA, and Meier E 1995 ; ligands with subnanomolar affinity and preference for the 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran and benzopyran piperidines. J Med Chem 38: 2009 2017. Monnet FP, Mahe V, Robel P, and Baulieu EE 1995 ; Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by NMDA in the rat hippocampus. Proc Natl Acad Sci USA 92: 3774 3778. Morin-Surin MP, Collin T, Denavit-Saubie M, Baulieu EE, and Monnet FP 1999 ; Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem. Proc Natl Acad Sci USA 96: 8196 8199. Nuwayhid S and Werling LL 2003 ; Sigma1 receptor agonist-mediated regulation of NMDA-stimulated [3H]dopamine release in dependent upon protein kinase C. J Pharmacol Exp Ther 304: 364 369. Rajkowski KM, Robel P, and Baulieu EE 1997 ; Hydroxysteroid sulfotransferase activity in the rat brain and liver as a function of age and sex. Steroids 62: 427 436. Ruppert R and Holsboer F 1999 ; Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 22: 410 416. Schuster DI, Arnold FJ, and Murphy RB 1995 ; Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain. Brain Res 670: 14 28. Snell LD, Iorio KR, Tbakoff B, and Hoffman PL 1994 ; Protein kinase C activation attenuates NMDA-induced increases in intracellular calcium in cerebellar granule cells. J Neurochem 62: 17831789. Su TP, London ED, and Jaffe JH 1988 ; Steroid binding at sigma receptors suggest a link between endocrine, nervous and immune systems. Science Wash DC ; 240: 219 221. Swartz S, Pohl P, and Zhou GZ 1989 ; Steroid binding at -"opioid" receptors. Science Wash DC ; 246: 16351637. Takahashi M, Luu-The V, and Labrie F 1990 ; Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3 -hydroxysteroid dehydrogenase 5 4-ene isomerase activity. J Steroid Biochem Mol Biol 37: 231236. Thomas P and Meizel S 1989 ; Phosphatidylinositol 4, 5 biphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent on upon Ca2 influx. J Biochem 264: 539 546. Vilner BJ and Bowen WD 2000 ; Modulation of cellular calcium by sigma-2 receptors: release from intracellular stores in human SK-N-SH neuroblastoma cells. J Pharmacol Exp Ther 292: 900 911. Werling LL 2002 ; Sigma receptor-active steroids and neurotransmitter release. Int J Psychopharmacol 5: S28. Werling LL, Frattali A, Portoghese PS, Takemori AE, and Cox BM 1988 ; Kappa receptor regulation of dopamine release from striatum and cortex of rat and guinea pig. J Pharmacol Exp Ther 246: 282286.
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Thirty 29.6% ; patients remained unresponsive to treatment. Thirty-two patients died, 17 15.7% ; of ITP bleeding, 11 patients; therapy complications, 6 patients ; and 15 13.9% ; of unrelated causes. We conclude that most patients with refractory ITP attain stable remission, though on average this occurs slowly. However, a subpopulation with severe, resistant disease experiences significant morbidity and mortality. Blood. 2004; 104: 956-960 and dolasetron.
The following table provides specific information about the adverse effects observed during the two controlled clinical trials in which a total of 99 patients received noritate.
The new life sciences have unleashed a number of ethical questions among the intellectuals and the public at large as no technology has done before, with the possible exception of atomic energy. It is no longer whether something is technologically feasible, but whether it is ethically desirable. Inherently, the public is disturbed at what they see as tinkering with the very building blocks of life, a tendency to play god, and self doubts as to whether we have the wisdom to make the right choices. Issues from the privacy of our DNA to the patentability of genetic material, from the rights of other species to the risks of unleashing unknown biological hazards, from GMOs to the costs of medicines, all raise questions of perceived risks and questionable appropriateness. The scientific community has lost much of the public's trust in its ability by itself to avoid the risks and make the right choices about the deployment of new technological advances. Less present in the debate is the cost of inaction on the new technologies and all the good that they can bring, especially to the poorer half of humanity. Here too some questions as to the appropriateness of the private sector patents and IPR regimes in relation to the public good need to be explored. All agree on the importance of the presence of a national, regional and even international code of bioethics, but something that would satisfy everyone, or at least the overwhelming majority like the Universal Declaration Of Human Rights did in the second half of the 20th century is still elusive Chair: Eric Huttner, General Manager, Diversity Arrays Technology Pty limited Australia ; Rapporteur: tba Peter Singer, Sun Life Financial Chair in Bioethics & Director, University of Toronto Joint Centre for Bioethics Canada ; Sandy Thomas, Director, The Nuffield Council on Bioethics, UK ; Ibrahim Badran, Former Minister of Health Egypt and doral.
Oxymetazoline ; nasal spray, loperamide imodium ad ; 2 mg caplets, stool softener docusate calcium 240 mg gelcaps.
Different tax rolls specify the landless parishioners to a widely varying extent. Accordingly this source material cannot tell us much concerning the rural proletariate. 161 Lennart Andersson Palm 1993 reports this criterion to be effective for eliminating landless nominati. Although he cites the limit as 3 Ne units, which is a somewhat more restrictive norm ; 162 On some of the homesteads not a single draught-animal possessor was registered, although the assessment of cattle and seed grain makes it clear that the farm was engaged in agricultural activity. The M S criterion thus excludes not only a person owning five cows but no other animals, like Matz Ion i Lundha Danmark 1571 ; , but also someone like Peter i Hendelp Gladhammar 1571 ; , richer than five sixths of the peasants in that parish and dovonex.
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In most countries the following were notable symptoms of policy failures: 1. Institutional weakness lack of expertise and poor infrastructure, e.g. vehicles, offices and funding ; . 2. Lack of ownership no institution has sole responsibility for co-ordinating the management of coastal resources except in Mozambique. 3. Absence of a legal framework and enforcement capabilities. 4. Inadequate lack of legislation governing access to communal coastal resources, i.e. fishing grounds, mangrove areas, dunes vegetation or beaches. 5. Poor coordination mechanisms between various institutions with mandates to manage coastal resources. 5. CONCLUSION The countries of the eastern African regions will need to develop a process at a national level with the following objectives: 1. Resource management: prepare and implement site-specific and management strate.
TABLE 6. RESEARCH PROGRAMMES OF THE EMGO INSTITUTE Research Programmes Programme Co-ordinators Senior investigators and postdocs and doxil.
For the third consecutive year, Cargas was named as one of the Best Places to Work in PA. The awards program, created in 2000, is one of the first of its kind offered by a state in the country. The program is a public private partnership of Team Pennsylvania Foundation, the Pennsylvania Department of Community and Economic Development, the Pennsylvania Chamber of Business and Industry, and the Central Penn Business Journal. This statewide survey and awards program was designed to identify, recognize and honor the best places of employment in Pennsylvania, benefiting the state's economy, its workforce and businesses. The Best Places to Work in PA program is made up of 100 companies split into two groups: 50 medium-sized companies 25250 employees ; and 50 large-sized companies 251 or more employees ; . Cargas has been named one of the Best Places to Work in PA in the medium category. To be considered for participation, companies had to fulfill the following eligibility requirements: - Have at least 25 employees in Pennsylvania; - Be a for-profit or not-for-profit business; - Be a publicly or privately held business; - Have a facility in Pennsylvania; and - Be in good standing with Commonwealth agencies under the Governor's jurisdiction. Companies from across the state entered the two-part process to determine the 100 Best Places to Work in PA. The first part consisted of evaluating each nominated company's workplace policies, practices, philosophy, systems and demographics. This part of the process was worth approximately 25% of the total evaluation. The second part consisted of an employee survey to measure the employee experience. Nearly 20, 000 Pennsylvania employees filled out the survey. This part of the process was worth approximately 75% of the total evaluation. The combined scores determined the top companies and the final ranking. Best Companies Group managed the overall registration and survey process in Pennsylvania with assistance from ModernThink LLC, who analyzed the data and used their expertise to determine the final rankings. Cargas will be recognized and honored at the Best Places to Work in PA evening awards ceremony on Tuesday, November 27, 2007, at the Hershey Lodge & Convention Center. The final rankings will be revealed at the ceremony. Tickets may be purchased online at centralpennbusiness events. In addition to the public private partnership, the program is supported by the following organizations: Team Pennsylvania Foundation, Sovereign Bank, E.K. McConkey & Co. Insurance, bmc, Rising Sun Consultants, Wendt Communication Partners and JPL Productions. For more information on the Best Places to Work in PA program, visit bestplacestoworkinpa or contact Beth Feltenberger at the Central Penn Business Journal at bethf journalpub or 717.236.4300. ABOUT CARGAS SYSTEMS Cargas provides business software and consulting, specializing in ERP, CRM and Human Resources. Established in 1988, Cargas fosters a unique corporate culture of employee ownership, shared values and a commitment to excellence that is evident in the quality of service they provide to their customers. Cargas was named the 2006 #1 Best Place to Work in PA in the medium-sized company category. Cargas is also the proud recipient of the prestigious Microsoft Business Solutions 2006 Consistent Performance Award, a recognition that honors the most consistent performing global partner over multiple consecutive years. With offices located in Lancaster and Pittsburgh, Pennsylvania, Cargas services the mid-Atlantic region. More information about Cargas can be found at cargas and docusate.
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The safety data were also remarkable in that there were no drug-related adverse events that were consistently associated with RAL in the two studies. For example, while headache was more frequently reported in BenchMrk-2 on RAL, it was more frequent on the placebo arm in BenchMrk-1. In terms of laboratory abnormalities, no single lab abnormality of grade 3 or greater at least grade 2 for ALT and AST ; severity was consistently at least 1% more likely on the RAL than placebo. For example, in BenchMrk-1, grade 2 AST levels were observed in 9.9% on RAL, 2.5% on placebo; in contrast in BenchMrk-2, these outcomes were noted in 8.3% and 7.6% respectively. In summary, RAL significantly increases the likelihood of achieving an undetectable viral load by week 16. The safety profile was very reassuring with few if any clear concerns and doxorubicin.
Title: Shave gel composition Publication No. USP 5, 888, 490 Application No. 938511 Date of filing 26 09 1997 Assignee: Colgate-Palmolive Co Described is a soap-free non-aerosol shave gel composition comprising an anionic surfactant, a betaine, a foam boosting non-ionic surfactant, an ethoxylated emollient and an ethoxylated glycoside ester of a diacid present as a gelling agent. The type of anionic surfactant, which comprise from about 10% to 15% of the composition, is not critical but preferred are ethoxylated alkyl sulfates. The betaine, representing about 4% to 6% of the composition, is selected for low irritation and mildness and a long-chain alkyl amide alkylene betaine such as cocamidopropylbetaine is suggested. Suitable non-ionic surfactants are foam boosters and preferably have thickening capabilities as well. The N-oxides satisfy these characteristics and dihydroxyethylcocoamine oxides and lauramidedihydroxyethyl and other long-chain alkyl amides are preferred. The non-ionic component is present at about 1.5% to 3%, by weight. The most preferred gelling agent is PEG-120 methyl glycoside dioleate, present from about 0.1% to 0.8% in the composition. Other additives include polyethylene glycols with a molecular weight of 400 to about 1000, which improve the foam characteristics by making it creamier. Humectants, UV stabilisers, fragrances, dyestuffs, and the other materials compatible with the gel may be added to enhance stability and its aesthetic qualities. Example formulation Sodium laureth sulfate 12.00%w w Cocamidopropylbetaine 5.00% Dihydroxyethylcocoamine Oxide 1.00% Lauramide DEA 0.75% PEG-120 methylglycoside dioleate 0.25% PEG-75 lanolin 1.50% Preservatives, fragrance, dyestuffs as required Water to 100% by weight!
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