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Many children seem not to notice the saliva until it is too late. When we get enough saliva in our mouths we swallow it automatically and thus we do not dribble. This does not seem to happen in children who dribble. Some children seem very unaware of what is in and around their mouths and can be messy eaters. Building up the child's awareness of saliva both inside and outside of the mouth is very helpful. Please be guided by your speech pathologist about which strategies are most appropriate. Battery operated vibrators can be used to stimulate the muscles in the cheeks and around the lips. Vibrators come in all sorts of shapes but you. Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 G.K., L.M.S. ; , and Cancer Center for Hematology, Texas Children's Hospital, M C3 3320, Houston, Texas 77030 A.R. ; Received September 5, 1996; Accepted April 18, 1997.

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Q. He and P. Joseph. Health Effects Laboratory Division, NIOSH, Morgantown, WV. Chromium containing compounds are extensively used in various applications resulting in significant human exposure. Several adverse health effects, including irritant and allergic contact dermatitis, have been reported among workers following occupational exposure to chromium containing compounds. In order to better understand the molecular mechanisms responsible for the dermal toxicity of chromium, differential gene expression profiles of human skin fibroblasts exposed to a cytotoxic concentration of hexavalent potassium dichromate [Cr VI ; ] were studied. Skin fibroblasts were exposed to 5 M for time intervals up to 24hr and their differential gene expression profile was studied using the Toxicology and Drug Resistance Microarray Super Array Inc. ; . Of the 280 genes represented on the array, the expression levels of 32 genes were found to be differentially affected in the fibroblasts exposed to Cr VI ; general, genes involved in stress response, cell cycle control, drug metabolism, apoptosis and growth were differentially expressed in response to Cr VI ; exposure. The role of intracellular glutathione on the Cr VI ; -induced alterations in the expression of genes was further investigated using heme oxygenase 1 HO-1 ; as the model gene. Modulating the intracellular glutathione level by pre-treating the cells with either BSO buthionineSulfoximine ; or glutathione significantly influenced the potential of Cr VI ; induce expression of the HO-1 gene. Pre-treating the cells with BSO resulted in a significant reduction in glutathione levels. The Cr-induced overexpression of the HO-1 gene in the BSO-treated cells was significantly higher than in those cells without BSO treatment. On the other hand, pre-treating the cells with glutathione partially blocked the Cr VI ; -induced overexpression of the HO-1 gene. In conclusion, our results demonstrate that Cr VI ; exerts its toxic effects in human skin fibroblasts by multiple mechanisms involved in various cellular functions; and the cellular glutathione level appears to be an important factor influencing Cr VI ; 's effects on the expression of genes.

Hand, stricter requirements from governments and civil society groups in relation to the benefits of these activities for the local population and the management of their environmental impacts. It is a huge challenge for industry and governments to reconcile these interests and ensure the sustainable production that brings concrete benefits to the local population, while not scaring off private investors that could bring value added to natural resources. c ; Efficiency-seeking FDI Mexico and the Caribbean Basin are long-standing recipients of FDI thanks to a combination of low costs and their proximity to the United States. A number of factors are threatening these comparative advantages, but the region seems to be adapting by creating new sources of competitive advantage. Mexico has lost competitiveness in low-technology segments such as wearing apparel see chapter III ; , and many companies have been closed down or transferred to Central America or Asia. Nevertheless, production costs in North America and the growing availability of skilled manpower have led some operators in more sophisticated sectors and activities to Mexico.42 In the face of the imminent restructuring of the United States automotive industry, Mexico seems well placed to receive new investments. After announcing the closure of plants in the United States, Ford representatives then announced an investment of US$ 560 million to expand the company's operations.43 Volkswagen, General Motors and DaimlerChrysler announced investments in new capacity, new plants or supplier development. Nissan, Mazda, Honda and Toyota are investing in new capacity Expansin, 2006b ; . One of the main reasons for the recent investments is the growth in demand in the United States for small, low-cost vehicles owing to high oil prices. The obstacles to be overcome in order to take advantage of proximity to the United States market include improvements in infrastructure, updating of the supply network and development of a more highly-skilled labour force that can help to attract. Respond or have a poor response to treatment.18 Although higher doses are given to unresponsive patients, the clinical efficacy of a standard initial dose of 4.8 g day has been mostly unexplored, until recently. To determine whether higher initial doses of 5-ASA would be as safe as lower doses while providing greater efficacy, in 2 randomized, phase 3, multicenter, double-blind, placebocontrolled studies, researchers compared a 4.8-g day dosage with a 2.4-g day dosage.19 In the first of these trials, ASCEND I Assessing the Safety and Clinical Efficacy of a New Dose of 5-ASA ; , the authors examined patients with mild-to-moderate UC, whereas, in ASCEND II, they focused primarily on patients with moderately active disease. In a pooled analysis of the 2 studies, 423 analyzable patients with moderately active UC were randomly assigned to receive delayed-release oral mesalamine in a dosage of either 4.8 g day 800-mg tablets ; or 2.4 g day 400-mg tablets ; for 6 weeks.18 The primary efficacy measure of the 2 studies was the percentage of patients who achieved overall improvement or treatment success at the end of the treatment period. Treatment success was defined as either complete remission or a clinical response to therapy, which was defined as an improvement in the baseline physicians' global assessment PGA ; and in at least 1 other physical assessment e.g., stool frequency, rectal bleeding, patient's functional assessment score [PFA], endoscopy findings ; without worsening in any other clinical assessment. Complete remission was defined as complete resolution of all symptoms with all assessment scores PFA and PGA ; equaling 0.19 A pooled analysis of the ASCEND I and II data showed that the rate of successful treatment was significantly higher among patients given oral mesalamine 4.8 g day 72% ; than among those given 2.4 g day 58%, P 0.05 ; .18 The data from ASCEND I alone, however, show that among patients with mild UC, the higher dosage was no more beneficial than the lower dosage. These findings suggest the benefit of the higher dosage would be evident only in patients with moderate UC.18, 19 In addition, patients taking mesalamine 4.8 g day demonstrated symptomatic relief significantly more quickly than did patients taking 2.4 g day. The median time to the resolution of rectal bleeding and a reduction in stool frequency was 19 days among patients given mesalamine 4.8 g day, compared with 29 days among patients taking 2.4 g day P 0.05 ; . Both doses of mesalamine had similar safety profiles, with the frequency and severity of adverse events being comparable.18 The results of these 2 studies suggest that the use of traditional low-dose 5-ASA induction therapy is best administered only to patients who have mild UC, whereas higher initial doses may be more efficacious in patients with moderate UC.19 Economics of UC According to a 1992 study, the total estimated annual medical cost associated with UC was ##TEXT##.4 to ##TEXT##.6 billion, with a perpatient annual cost of , 488.20, 21 Of this total cost, medical services, such as the diagnostic work-up, outpatient services and follistim.

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TABLE 2. Forearm Blood Flow in Relation to Perfusion Pressure in Three Normal Subjects Subject 1 Variable 2 24 Age yr ; 21 95 100 Blood pressure mm Hg ; 75 Reduced perfusion pressure mm Hg ; 75 Row 1 ml 100 ml tissue min ; 6.8 3.0 1.9 ; How 2 ml 100 ml tissue min ; 1.3 43% ; 6.3 93% ; 2.6 87% ; How 3 ml 100 ml tissue min ; Numbers in parentheses represent flow 2 and flow 3 as a percentage of flow 1. 3 22 Average 22 100 78 ; 3.8 88. From this place. Moat of the fartn- Red Bank road, la laid up Vvith a ors c u t "gr" f o r their own usesprained back. Ho mot with thii inlast week, b u t they did not g e t last jweek wlnlo cranking a tractor. enough to make shipments. The Jann&rono construction com- . William O'Brien of J e City M r a Mrs ""William Carney nt 5 ewrWui * .umn.w PR SPRtMl * pany w u tho lowest bidder f o r pav- spent two days' last week with Ber tended t h o funeral last Wednesday ing t h e West Long Branch" and I n - nard Kelly 2 8 B Street terlakcn roads when bids were Mr. and Mrs, Lewis g Thompson, oponod by the freeholders last week who a r e New York home, Tho J a n company's estimate spent last week here. They expect waa , 702.83. Tho freeholder, to move t o their summer homo a t approved plans for replacing the as- Brookdalo farm in a few days. phalt paxement n t Galilee, whjch J o a Mullin, who-has afinep o was destroyed by a storm last win- altion in a bank a t Trenton, spent ter part of laat week with his father, Wombeis of the board with Sher- Matthew Mullin. iff Harry N Johnaon made an inJ o h n KIcrnan, who is in training spection of tho county work house at Brookdalc farm to take part in a ot Middlesex county yerturday This pugilistic match, fipent Saturday 0 n d was the first of a nones of visits to Sunday a t his homo a t Long Branch. t 9t00 A. M. be made with Hip idea of obtaining Robert MeClaln h a s new Star information as to tho operation of sedan. SEE PAGE 3 county work houses and f a r Mrs. John Kilhleaihave n . - - returned from Sunny Mill, Georgia, COLT'S NECK N E W and they aro occupying their home at Brookdalo farm. Mr. Killilea la A Big- M e e t Lewis S Thompson's butler and ho Committee Looked f o r Friday. Thousands B 1 M Or. Leonhardt, tha was with M r Thompson during tho A laige~atti ndallce la looked fofl winter while Mr. Thompson w a i Dlicovored Thit at a meeting of the Atlantic town- Sunny Hill. Comuou 5eni Remedy tliip committee, which will b e held David Hood h a s moved from t h e you think thflt the surgeon's at the township hall a t this place Freston hQuse to his own house on knife is tho only method af cieupe F u d afternoon Tho principal the Holmdcl road from tho misery of pilca, it's be biihippHH hi-forr * tho committee --One--o-f H a r r Payno Whitney's eauao you-hav n't heard of tho new that of awarding a contract f o r horaca won a big race a t Bowie, t r e a known as Dr. Leonhardt' proving and graveling Kentucky, Inst Friday, The horse "This experimenting, ho dia -tween--the villain- c e n t lhe was trained on-Mr, Whitncy !s farm t e r line-. at this place, covered tho cauae of pile j and tiien Rev J A Thomson will move Joseph W. Thompson has repaint w e n further and compounded a fiom Middlctown village this week ed lua house on the Red Bank road remedy that would remove t h e tiiko charge of t h Reformed cause. Mr and Mrs William Domidion COMFORT lWcry pile sufferer should bene church a t this place H e will preach and family of New York spent last fit by his discovery a n d that his first sermon as pastor of the week on the Dr. Kerr f a r the throuqh t h e will bo n o doubting o r dcluyi church here next Sunday FLEXHMLITY-- Red Bank road, which they recently tho United Retail Chcmistp and r A numher of Ticchold folks had in tho They spent moat of t h all druggists a r o uuthoilzcd t o hell a birthday dinner p a i Saturday bought week planting fruit trce a. HFMt-ROID with guarantee that it will do as stated o r money back night nt Emil Hofmun's hotel -White Lcghorna a r e supposed Some asparagus cuttings ]iave to bo goad setting hens, b u t one On that honorable basis every sufferer-should securo n package of been made and it -is probable t h a owned by Mrs. H a r Langendorf D r . Leonhordt's HEM-ROID today. thc~first shipments will t a k placo- [iatchcd t1\irtceinehicks from-thirthe coming week. Up t o pres teen eggs laBt-wcek, ; 6 2 1 C Ave., ent time tho farmers have gathered Theodore Molloy, who Is In enough grass only for t h e tabic charge of tho Allen place on the use. Tho cold weather t h e latter pnit of last week act the crop hack Honry Carney, who lives on one of tho Brjikelcy farms on t h Freehold road, lias a new Chevrolet landau. H e useB i t t ride t o a from hii work a t Hed Bank, where he is employed by the 5 . S Thompson company August ISoffcl is making a number of impiovements t o his property in tho village center Mr Soffel is one of t h moat enthusiastic gardeners , n th.a section and ha always has a. big lot of flowers, fruit a n d voge. SomtthlngsitnproyieLwlth tables.-- L., . ! thinia tor boys - The~ p o t acreage. i n Atlantic iowjuhiB J appjarently about the Tirerjust as good a t a same s ifrorn3LUp aBdJhjt tpe n|, may b a a last year, "although-there e slight increase In t h acreas good a s can be. age duo t o t fact t h a several P e r Spring we're featur- farms which were not tilled last year are being operated this season. iag: yalentino Jtowalsky h a s new Boys Junior-- soft-collar e n r f coat ihirts, ages 10 t o 13, from the' William 0 . E estate of J ' like big brother's i i n Holmdel. LINCROFTNEWS. plain and fancy broadcloths' and fortovase.

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