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1, 2-diacylglycerophospholipids consist of two fatty acids in sn-1 and sn-2 position and an esterified phosphate group in position sn-3 on a glycerol backbone. Figure 1.2.4 ; We find different alcohols on the phosphate, defining the glycerophospholipid class. At neutral pH phosphatidylcholine PC ; and phosphatidylethanolamine PE ; have a net zero charge while phosphatidylserine PS ; and phosphatidylinositol PI ; carry a net negative charge -1 ; . The acyl-chains in position sn-1 and sn-2 vary in length of the carbon chains and the degree of saturation. The fatty acids in position sn-1 are normally saturated, and in position sn-2 we find different unsaturated fatty acids.
Objectives. We sought to assess the effects of combined oral positive inotropic and beta-blocker therapy in patients with severe heart failure. Background. Patients with severe, class IV heart failure who receive standard medical therapy exhibit a 1-year mortality rate 50%. Moreover, such patients generally do not tolerate betablockade, a promising new therapy for chronic heart failure. Positive inotropes, including phosphodiesterase inhibitors, are associated with increased mortality when administered over the long term in these patients. The addition of a beta-blocker to positive inotropic therapy might attenuate this adverse effect, although long-term oral inotropic therapy might serve as a bridge to beta-blockade. Methods. Thirty patients with severe heart failure left ventricular ejection fraction [LVEF] 17.2 1.2%, cardiac index 1.6 0.1 liter min per m2 ; were treated with the combination of oral enoximone a phosphodiesterase inhibitor ; and oral metoprolol at two institutions. Enoximone was given at a dose of 1 mg kg body weight three times a day. After clinical stabilization, metoprolol was initiated at 6.25 mg twice a day and slowly titrated up to a target dose of 100 to 200 mg day.
Munication. Archaeologists look to television as the prime target to approach. Newspapers and magazines are secondary, obviously restricted to that literate portion of the society accustomed to reading. Archaeology publications aimed at the nonspecialist, ranging from comic formats to glossy high-end magazines, reach different sectors of the society. However, the demand for information at all levels of interest, under the guise of entertainment, is a constant. Thus, the media are the fundamental sources of knowledge for many community members, school-aged and beyond. Few commercial broadcasters reflect a social conscience or an interest in furthering knowledge, but there are exceptions. On the other hand, some radio and television stations, usually state and or NGO-supported, often try to reach specific sectors of society through such devices as culturally oriented programming including traditional indigenous music, political discussions and commentary, educational topics, indigenous-language programming, among other features ; . The popularity in Mexico of dubbed editions of Discovery Channel and National Geographic documentaries, some of which are in fact dedicated to archaeology, is notorious. However, the majority of these are transmitted on cable networks rather than public television, greatly restricting access to the part of society that is more inclined, both economically and educationally, to already have an interest in scientific topics. Museums are a significant element and provide broad opportunities for communication of different aspects of the past through new technologies as well as the display of objects. Again, while not all sectors of society have access to museums, they are open without cost to students and educators. As they have become a major complement to primary and secondary education through periodic visits, it is the responsibility of the museum staff to periodically update exhibits, supplementary information, and resources such as video and live presentations for the public's benefit. Museums are frequently found at archaeological sites, and their condition is largely a function of the importance of the site itself and the number of visitors it receives. Another interesting element is the concept of the community museum. A number of archaeologists have managed to foster the interest of the rural communities in which sites are located by stimulating the creation of local exhibits based on small permanent collections of materials obtained during excavation. Often these installations are inaugurated with great fanfare, only to be abandoned as time goes by and the archaeologist is no longer working in the area. Nevertheless, it might be argued that such efforts, however small, are valuable undertakings. Undoubtedly, archaeologists must exit the ivory tower and share the knowledge their scientific research generates. How? This can be accomplished by encouraging and collaborating in the creation of attractive programming in different media accessible to all sectors of the public and by actively participating in events aimed at different groups, including conferences, "hands-on.
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CORRESPONDING AUTHOR: Department of Social and Preventive Dentistry Medical University of Bialystok ul. Akademicka 3, 15-276 Bialystok, Poland Tel. + 48 085 748 fax: + 48 085 748 e-mail: helpdentamb tlen Received 21.03.2006 Accepted 30.03.2006.
Ibritumomab tiuxetan has recently become commercially available and wider use will bring familiarity with the product. After lengthy discussions with the FDA over the past few years, iodine I 131 tositumomba will finally be presented to the Oncologic Drug Advisory Committee to the FDA on December 17, 2002. A number of clinical trials are focused on optimizing strategies for incorporating RICs into the treatment of patients with NHL. Currently, yttrium Y 90 ibritumomab tiuxetan is approved for use in relapsed or refractory follicular, low-grade, or transformed NHL, and in patients in whom rituximab therapy fails. In general, RICs should be used in patients in whom chemotherapy and rituximab have failed. For some patients who have had an initial, durable response to rituximab, a second course of that unconjugated antibody may induce a meaningful response.77 Whether it is advantageous to use an RIC as part of initial treatment or to reserve it for a salvage option is under investigation. Response rates with RICs inversely correlate with the extent of prior therapy, whereas the likelihood of toxicity increases, notably MDS.56 However, use of an RIC as initial therapy is currently investigational because of the potential adverse effects and a lack of data demonstrating prolongation of survival. When physicians are eventually faced with how to decide among multiple RICs, one leading criterion in that determination will be the overall activity response rate and duration of response. Yet, the activity of an RIC may vary with specific indications; for example, the longer path length of 90Y may be preferable to 131I for bulky disease, whereas the lack of affinity of 131I to bone may induce less pronounced hematologic toxicity. Comparisons of results of RICs may be confounded by differences in patient features, including the type and amount of prior therapy and response to that therapy, and differences in response criteria.78 Another factor may be which RIC induces the least myelosuppression or lowest risk of secondary malignancies. One critical deciding factor may be which agent is the most convenient and cost-effective. Validating clinical utility and safety outside of well-controlled trials is key to the overall success of this new class of drugs. However, direct comparisons of currently available RICs are of limited interest because the number of patients required to detect a meaningful difference in efficacy would be prohibitively large and may be more prominent in subsets of patients. Detecting important differences in toxicities would also be difficult. Both ibritumomab tiuxetan and tositumomab are associated with substantial grades 3 and 4 myelosuppression, but these occurrences are not as clinically relevant as are the risk of infections, and requirements for blood component or growth factor support, which are relatively low for both agents. Attempts to optimize the use of RICs include pretargeting to safely improve biodistribution and improve efficacy.79 Weiden et al80 administered rituximab conjugated to streptavidin to bind to tumor-associated antigen receptors, followed by biotin-N-acetylgalactosamine to remove nonlocalized conjugate from the circulation. The tumor-towhole-body radiation dose following the chelatebiotin ligand labeled with 111In for imaging and 90Y for therapy was higher than previously observed without pretargeting; response rates in the 10 patients were considered encouraging, and toxicity was reportedly mild. Most important, RICs should form the basis of more effective, multiagent therapies, combined with chemotherapy, other antibodies or biologics.81, 82 Combining RICs with chemotherapy will be a challenge because of the overlapping myelosuppression, and sequencing these modalities may be the necessary alternative.64 and idarubicin.
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This paper presents three pruning algorithms based on Optimal Brain Surgeon OBS ; and Unit-Optimal Brain Surgeon Unit-OBS ; . The first variant performs a backward selection by successively removing single weights from the input variables to the hidden units in a fully connected multilayer perceptron MLP ; for variable selection. The second one removes a subset of non-significant weights in one step. The last one combines the two properties presented above. Simulation results obtained on the Monk's problem illustrate the specificities of each method described in this paper according to the preserved variables and the preserved weights.
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Patent Abstracts John Woodruff Date of filing 16 01 1996 Assignee: Stepan Co. Deployment of the sunscreen molecules over the surface of the skin determines to a major extent the protection delivered by various sunscreen formulations. Ideally, the sunscreen formulation should be applied to yield a film of uniform thickness on the skin with the sunscreen molecules homogeneously distributed within the film. The base formulation determines the manner in which the sunscreen molecules are deployed on the skin and also affects the ability of a sunscreen to protect skin after prolonged water exposure. The most common formulation type for topical sunscreens is an emulsion, either oil-inwater o w ; or water-in-oil w o ; . It important that the emulsification system be capable of creating stable emulsions with a variety of polar and non-polar sunscreen agents as well as cosmetic oils. The patent claims methods and compositions for increasing the sun protection factor of sunscreen emulsions by adding a phthalic acid derivative in an amount effective to increase the sun protection factor of the composition. Most preferred sunscreen emulsions of the invention comprise about 1 to 5% of the phthalic acid derivative by weight and examples of these are sodium soyaamido benzoate, sodium oleylamido benzoate, potassium cocoamido benzoate, and sodium stearylamido benzoate. The emulsions may be either w o or and may include any permitted sunscreen active, alone or in combination. The patent describes various test formulations and results show a significant improvement in SPF when sodium benzoate and other phthalic acid derivatives are included in the compositions. Title: Sun screening agents in the form of oil water micro emulsions Publication No. USP 6, 207, 140 Application No. 254946 Date of filing 19 03 1999 Assignee: Cognis, Germany Micro-emulsions are optically isotropic, thermodynamically stable systems that contain oil components, emulsifiers and water. The transparent appearance of micro-emulsions is attributable to the small particle size of the dispersed emulsion droplets. In the range from 100 to 300 nm micro-emulsions are brown-red in transmitted light and a shimmering blue in reflected light. They are clear when the droplet size is below 100 nm in diameter. The applicants claim that there is a continuing need on the market for sun protection products with an improved performance spectrum. Of particular interest in this regard are compositions that enable relatively large amounts of UV filters to be incorporated without any phase separation or sedimentation occurring during storage. Where relatively large quantities of titanium dioxide are incorporated, a formulation produced by the phase inversion temperature PIT ; method tends to separate the dispersed solid very quickly. Another problem is that many UV filters are capable of interacting with the other ingredients of the formulation, resulting in a chemical reaction and also in a reduction in storage stability. Finally, consumers prefer transparent formulations, which show high skin-cosmetic compatibility, even when applied to very sensitive skin.
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Pure antagonist by shifting the conformational equilibrium of the ARE709Y CPA complex toward the inactive conformation. Inversely, the same mutation allows the ARE709Y bicalutamide complex to transiently adopt the active conformation, thereby converting bicalutamide into a partial agonist. Coactivator and Corepressor Interactions with wt-AR and ARE709Y Paralleling our observations, it has been previously reported that the mutation homologous to ARE709Y in ER ER D351Y ; changes the pharmacology of raloxifene or tamoxifen by shifting their antiestrogenic activity to an estrogenic activity 1923 ; . Whereas tamoxifen promotes association between wt-ER and corepressors, Yamamoto et al. 24 ; reported that ER D351Y exhibits a reduced tamoxifen-induced interaction with nuclear receptor corepressor silencing mediator of retinoic acid and thyroid hormone receptor SMRT ; and consequently a high tamoxifen-induced and iloprost!
TO THE EDITOR: The proposal in the editorial by Drs. Yudofsky and Hales gives me pause. What is the difference between this proposal and the ones made by others 1, 2 ; ? If the answer is that they continue to include the psychodynamic, interpersonal, and other psychosocial perspectives, do they propose a continuation of psychotherapy training in residency training programs? If not, how are these perspectives to be transmitted? What about retraining for current physicians? The point about two medical specialties treating disorders of the central nervous system is inaccurate. There are cur.
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Risk Factors Associated with Increased Rates of Adverse Events: Administration of RITUXAN weekly for 8 doses resulted in higher rates of Grade 3 and 4 adverse events17 overall 70% ; compared with administration weekly for 4 doses 57% ; . The incidence of Grade 3 or 4 adverse events was similar in patients retreated with RITUXAN compared with initial treatment 58% and 57%, respectively ; . The incidence of the following clinically significant adverse events was higher in patients with bulky disease lesions 10 cm ; N versus patients with lesions 10 cm N 195 ; : abdominal pain, anemia, dyspnea, hypotension, and neutropenia. Infusion Reactions See BOXED WARNINGS and WARNINGS ; : Mild to moderate infusion reactions consisting of fever and chills rigors occurred in the majority of patients during the first RITUXAN infusion. Other frequent infusion reaction symptoms included nausea, pruritus, angioedema, asthenia, hypotension, headache, bronchospasm, throat irritation, rhinitis, urticaria, rash, vomiting, myalgia, dizziness, and hypertension. These reactions generally occurred within 30 to 120 minutes of beginning the first infusion, and resolved with slowing or interruption of the RITUXAN infusion and with supportive care diphenhydramine, acetaminophen, IV saline, and vasopressors ; . In an analysis of data from 356 patients with relapsed or refractory, low-grade NHL who received 4 N 319 ; or 8 N weekly infusions of RITUXAN, the incidence of infusion reactions was highest during the first infusion 77% ; and decreased with each subsequent infusion 30% with fourth infusion and 14% with eighth infusion ; . Infectious Events: RITUXAN induced B-cell depletion in 70% to 80% of patients and was associated with decreased serum immunoglobulins in a minority of patients; the lymphopenia lasted a median of 14 days range, 1 to 588 days ; . Infectious events occurred in 31% of patients: 19% of patients had bacterial infections, 10% had viral infections, 1% had fungal infections, and 6% were unknown infections. Incidence is not additive because a single patient may have had more than one type of infection. Serious infectious events Grade 3 or 4 ; , including sepsis, occurred in 2% of patients. A report in the literature described an increase in fatal infection in HIV-related lymphoma patients when RITUXAN was used in combination with CHOP chemotherapy as compared to CHOP alone. Hematologic Events: In clinical trials, Grade 3 and 4 cytopenias17 were reported in 48% of patients treated with RITUXAN; these include: lymphopenia 40% ; , neutropenia 6% ; , leukopenia 4% ; , anemia 3% ; , and thrombocytopenia 2% ; . The median duration of lymphopenia was 14 days range, 1 to 588 days ; and of neutropenia was 13 days range, 2 to 116 days ; . A single occurrence of transient aplastic anemia pure red cell aplasia ; and two occurrences of hemolytic anemia following RITUXAN therapy were reported. In addition, there have been a limited number of postmarketing reports of prolonged pancytopenia, marrow hypoplasia, and late onset neutropenia defined as occurring 40 days after the last dose of RITUXAN ; in patients with hematologic malignancies. In reported cases of late onset neutropenia NCI-CTC Grade 3 and 4 ; , the median duration of neutropenia was 10 days range 3 to 148 days ; . Documented resolution of the neutropenia was described in approximately one-half of the reported cases; of those with documented recovery, approximately half received growth factor support. In the remaining cases, information on resolution was not provided. More than half of the reported cases of delayed onset neutropenia occurred in patients who had undergone a prior autologous bone marrow transplantation. In an adequately designed, controlled, clinical trial, the reported incidence of NCI-CTC Grade 3 and 4 neutropenia was higher in patients receiving RITUXAN in combination with fludarabine as compared to those receiving fludarabine alone 76% [39 51] vs. 39% [21 53] ; .18 In patients with Waldenstrom's macroglobulinemia, following initiation of RITUXAN therapy transient increases in serum IgM levels have been observed which may result in hyperviscosity syndrome requiring plasmapheresis. Cardiac Events See BOXED WARNINGS ; : Grade 3 or 4 cardiac-related events include hypotension. Rare, fatal cardiac failure with symptomatic onset weeks after RITUXAN has also been reported. Patients who develop clinically significant cardiopulmonary events should have RITUXAN infusion discontinued. Pulmonary Events See BOXED WARNINGS ; : 135 patients 38% ; experienced pulmonary events in clinical trials. The most common respiratory system adverse events experienced were increased cough, rhinitis, bronchospasm, dyspnea, and sinusitis. In both clinical studies and post-marketing surveillance, there have been a limited number of reports of bronchiolitis obliterans presenting up to 6 months post-RITUXAN infusion and a limited number of reports of pneumonitis including interstitial pneumonitis ; presenting up to 3 months postRITUXAN infusion, some of which resulted in fatal outcomes. The safety of resumption or continued administration of RITUXAN in patients with pneumonitis or bronchiolitis obliterans is unknown. Immune Autoimmune Events: Immune autoimmune events have been reported, including uveitis, optic neuritis in a patient with systemic vasculitis, pleuritis in a patient with a lupus-like syndrome, serum sickness with polyarticular arthritis, and vasculitis with rash. Less Commonly Observed Events: In clinical trials, 5% and 1% of the patients experienced the following events regardless of causality assessment: agitation, anorexia, arthritis, conjunctivitis, depression, dyspepsia, edema, hyperkinesia, hypertonia, hypesthesia, hypoglycemia, injection site pain, insomnia, lacrimation disorder, malaise, nervousness, neuritis, neuropathy, paresthesia, somnolence, vertigo, weight decrease. OVERDOSAGE There has been no experience with overdosage in human clinical trials. Single doses of up to 500 mg m2 have been given in controlled clinical trials.10 DOSAGE AND ADMINISTRATION Initial Therapy: RITUXAN is given at 375 mg m2 IV infusion once weekly for 4 or 8 doses. Retreatment Therapy: Patients who subsequently develop progressive disease may be safely retreated with RITUXAN 375 mg m2 IV infusion once weekly for 4 doses. Currently there are limited data concerning more than 2 courses. RITUXAN as a Component of ZevalinTM Ibritumomab Tiuxetan ; Therapeutic Regimen: As a required component of the Zevalin therapeutic regimen, RITUXAN 250 mg m 2 should be infused within 4 hours prior to the administration of Indium-111- In-111- ; Zevalin and within 4 hours prior to the administration of Yttrium-90- Y-90- ; Zevalin. Administration of RITUXAN and In-111-Zevalin should precede RITUXAN and Y-90-Zevalin by 7 9 days. Refer to the Zevalin package insert for full prescribing information regarding the Zevalin therapeutic regimen. RITUXAN may be administered in an outpatient setting. DO NOT ADMINISTER AS AN INTRAVENOUS PUSH OR BOLUS. See Administration. ; Instructions for Administration Preparation for Administration: Use appropriate aseptic technique. Withdraw the necessary amount of RITUXAN and dilute to a final concentration of 1 to mg mL into an infusion bag containing either 0.9% Sodium Chloride, USP, or 5% Dextrose in Water, USP. Gently invert the bag to mix the solution. Discard any unused portion left in the vial. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. RITUXAN solutions for infusion may be stored at 28C 3646F ; for 24 hours. RITUXAN solutions for infusion have been shown to be stable for an additional 24 hours at room temperature. However, since RITUXAN solutions do not contain a preservative, diluted solutions should be stored refrigerated 28C ; . No incompatibilities between RITUXAN and polyvinylchloride or polyethylene bags have been observed.
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Table 2. Multivariate analysis of risk factors associated with t-MDS t-AML cohort study ; Total Cohort n 612 ; Relative Risk 95% CI * ; Hodgkin's Disease n 218 ; Relative Risk 95% CI * ; Non-Hodgkin's Lymphoma n 394 ; Relative Risk 95% CI and ibritumomab.
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Exposure to Secondhand Smoke and its Surveillance I34 ; 240-1: Building up Tobacco Free Hospital in Beijing Chaoyang Hospital Dan Xiao, China 240-2: Canadian Tobacco Use Monitoring Survey: a Success Story Murray, J. Kaiserman, Canada 240-3: A 20-Country Comparison of Levels of Indoor Air Pollution in Different Workplaces Andrew Hyland, USA 240-4: Evaluation of the implementation of the new smoking ban among the employees of the prevention department of the italian Ministry of Health Stefania Vasselli, Italy 240-5: Smoke-Free Spaces: Lessons from a Better Practices Review of a Population-Health Intervention Candace I.J. Nykiforuk, Canada.
A number of medical conditions may alter immune responsiveness and predispose a person to TB. Such disorders include HIV infection, immunosuppressive therapy, hematologic or reticuloendothelial malignancies, chronic renal failure, diabetes, and malnutrition. These conditions may influence the outcome of therapy. Therapeutic decisions for the impaired host must be individualized. Patients with partial impairment of renal function should avoid streptomycin, kanamycin, and capreomycin if possible. If renal function is severely impaired, reduced doses or increased dosing intervals of other TB drugs may be necessary see table 7, pp. 124 ; . Measurement of drug serum levels may be helpful in adjusting the dosage. For patients who abuse alcohol or who have neuropsychiatric disorders, close supervision -- preferably using DOT -- is necessary to ensure adherence and to monitor for adverse reactions to medications and invirase.
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Appropriate individuals, organisations and sponsors together to develop learning networks and enable the efficient dissemination of information and education to PCPs; Enable coherent and whole systems approaches to dealing with neurological conditions and the multiple morbidities that are often present. Interest in the society has steadily grown throughout its first year, with nearly 300 people attending the first two conferences in 2005, and over 1000 people registered with the Society See Map ; . In addition to raising awareness and stimulating interest in neurology across primary care via its conferences, the Society is also generating interest via its website, which it plans to update in the next few weeks, and of course this newsletter, which is currently being provided four times a year. The Society's main area of development for 2006 2007 will be to focus on its major goal of encouraging the sharing of best practice as well as supporting the provision of education and information to and iressa.
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