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Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardiovascular disease. Diabetes Care 27: 28872892, 2004 Blackburn H, Keys A, Simonson E, Rautaharju P, Punsar S: The electrocardiogram in population studies: a classification system. Circulation 21: 1160 1175, Langer A, Freeman MR, Josse RG, Steiner G, Armstrong PW: Detection of silent myocardial ischemia in diabetes mellitus. J Cardiol 67: 10731078, 1991 Hume L, Oakley GD, Boulton AJ, Hardisty C, Ward JD: Asymptomatic myocardial ischemia in diabetes and its relationship to diabetic neuropathy: an exercise electrocardiography study in middle-aged diabetic men. Diabetes Care 9: 384 388, Koistinen MJ: Prevalence of asymptomatic myocardial ischaemia in diabetic subjects. BMJ 301: 9295, 1990 Prevalence of unrecognized silent myocardial ischemia and its association with atherosclerotic risk factors in noninsulindependent diabetes mellitus. Milan Study on Atherosclerosis and Diabetes MiSAD ; Group. J Cardiol 79: 134 139, Chiariello M, Indolfi C, Cotecchia MR, Sifola C, Romano M, Condorelli M: Asymptomatic transient ST changes during ambulatory ECG monitoring in diabetic patients. Heart J 110: 529 534, Naka M, Hiramatsu K, Aizawa T, Momose A, Yoshizawa K, Shigematsu S, Ishihara F, Niwa A, Yamada T: Silent myocardial ischemia in patients with non-insulin-dependent diabetes mellitus as judged by treadmill exercise testing and coronary angiography. Heart J 123: 46 53, Janand-Delenne B, Savin B, Habib G, Bory M, Vague P, Lassmann-Vague V: Silent myocardial ischemia in patients with diabetes: who to screen. Diabetes Care 22: 1396 1400, Valensi P, Sachs RN, Harfouche B, Lormeau B, Paries J, Cosson E, Paycha F, Leutenegger M, Attali JR: Predictive value of cardiac autonomic neuropathy in diabetic patients with or without silent myocardial ischemia. Diabetes Care 24: 339 343, Inoguchi T, Yamashita T, Umeda F, Mihara H, Nakagaki O, Takada K, Kawano T, Murao H, Doi T, Nawata H: High incidence of silent myocardial ischemia in el.
From the Clinical Research Initiative in Heart Failure, University of Glasgow, Scotland J.M. ; , and the Cardiovascular Division, Brigham and Women's Hospital, Boston, Mass M.A.P. ; . This is Part I of a 2-part article. Part II will appear in the May 7, 2002, issue of Circulation. Both authors have received research support for clinical trials and honoraria for advisory boards, lectures, and other activities related to a number of the pharmacological agents mentioned in this review. Correspondence to Dr. John J.V. McMurray, Clinical Research Initiative in Heart Failure, University of Glasgow, Wolfson Building, Glasgow G12 8QQ, Scotland. Circulation 2002; 105: 2099-2106. ; 2002 American Heart Association, Inc. Circulation is available at : circulationaha DOI: 10.1161 01.CIR.0000014763.63528.9D.
1. Wingard JR, Mellits ED, Sostrin MB, et al. Interstitial pneumonitis after allogeneic bone marrow transplantation. Nine-year experience at a single institution. Medicine Baltimore ; 1988; 67: 175186. Weiner RS, Bortin MM, Gale RP, et al. Interstitial pneumonitis after bone marrow transplantation: assessment of risk factors. Ann Intern Med 1986; 104: 168175. Kantrow SP, Hackman RC, Boeckh M, Myerson D, Crawford SW. Idiopathic pneumonia syndrome: changing spectrum of lung injury after marrow transplantation. Transplantation 1997; 63: 10791086. Slavin S, Nagler A, Naparstek E, et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 1998; 91: 756763. Glucksberg H, Storb R, Fefer A, et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974; 18: 295304. Breuer R, Or R, Lijovetzky G, et al. Interstitial pneumonitis.
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Commission" means the Wisconsin waterways commission established under, s. 15345 1 ; . b ; "Governmental unit" means the department, a municipality, a public inland lake protection and rehabilitation district organized under ch ., 33 or the Fox river management commission. c ; "Recreational boating facilities" means places where the public has access to the water by means of breakwaterss and other, similar physical structures, either naturally or artificially constructed, which provide safety and convenience for operators of recreational watercraft . "Recreational boating facilities" also includes locks and facilities which provide access between waterways for operators of recreational watercraft., Recreational boating facilities on the Great Lakes are commonly referredd to as harbors of refuge . Recreational boating facilities on inland waters aree commonly referredd to as public accesses or launching ramps . 2 ; STUDIES . a ; The commission mayy cause to be conducted appropriate studies, including feasibility studies, and and parnate.
Table 1 Clinical characteristics of patients responding or not responding to first line treatment univariate analysis ; Responders Non Responders P Number patients 150 71% ; 61 29% ; Donor type HLA SIB Unrelated Donor Age : median range ; Female D in to male R Recipient age : median range ; Disease Early disease Conditioning with TBI Number cells infused x10 8 kg GvHD prophylaxis CsA MTX Grade of GvHD at registration I II III-IV Interval Tx-GvHD dd ; Alive Follow up surviving patients Follow up deceased patients Transplant related deaths Leukemia related deaths 80 70 36 ; 26% ; 32 6-66 ; 73 49% ; 96 64% ; 4.6 0.7-12.2 ; 146 98% ; 91 61% ; 49 10 16 ; 84 56% ; 1176 129-1930 ; 203 9-1809 ; 40 27% ; 26 17% ; 30 31 42 ; 10 16% ; 34 2-64 ; 21 35% ; 39 66% ; 4.6 6.0-17 ; 59 97% ; 24 39% ; 27 10 17 ; 22 36% ; 1134 37-1969 ; 101 15-1056 ; 30 49% ; 9 15.
| Papaverine erectionFluorescent Diamonds do not always emit the color blue. Sometimes they emit a variety of other colors such as green or yellow. Also some diamonds are so strongly fluorescent that they can be stimulated with any light containing wavelengths near 380 nm - for example, ordinary blue light at about 400-450 nm. The result is that the perceived color of a fluorescent stone is very dependent on the light used to observe it, and it may be difficult to grade accurately under any circumstances and paromomycin
Testified that the stroke had left Monahan "unable to perform The exact time the stroke occurred is unknown because it was a "stroke in evolution" in that it "progresses it starts, and it goes on for a few hours." One of Monahan's expert witnesses testified that it most likely occurred "while [Monahan] was being transported to Riverside." 6.
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Four soldiers will be reprimanded for forcing two Iraqi detainees to jump off a bridge into the Tigris River earlier this year, a military spokesman said. There have been questions about whether one of the Iraqis died, but Fort Carson spokesman Lt. Col. Thomas Budzyna said no one was killed. The soldiers, based at Fort Carson, were part of a 3rd Brigade Combat Team led by Lt. Col. Nate Sassaman, a star quarterback at West Point in the mid 1980s, Budzyna said Tuesday. Budzyna said he had no other information, and Sassaman did not return a call to his office. Now we get the real Sassaman: real brave when giving sound bites about killing Iraqis, but too cowardly to answer his phone. ; Sassaman has been reprimanded for helping others mislead Army investigators about the incident, the Post reported, citing unidentified officers familiar with the situation. Sassaman told The Associated Press in December that Samarra has been a "thorn in our side, " then vowed to crack down on insurgents and pbz.
| Orrhagia and epistaxis were poor predictors of the disease while cutaneous bleeding and bleeding after dental extractions were more sensitive symptoms for diagnosis.14 A bleeding score has been developed Table 3 ; and was validated in affected and nonaffected members of 154 families enrolled prospectively in a large European study, as well as in 200 normal individuals.15.
Have shown that the effect of papaverine is short-lived 1719 ; and that it has notable adverse effects, including hemodynamic compromise, increased intracranial pressure ICP ; 20, 21 ; , seizures 22 ; , and even paradoxical worsening of vasospasm 19 ; . Kaku et al 12 ; reported that an IA infusion of papaverine resulted in a sustained treatment of vasospasm; they believed that the early timing of treatment was crucial in achieving optimal effectiveness. Results of subsequent experimental models have been consistent with this concept. However, each of the vessels in the study by Kaku et al was also treated with 0.51.0 mg of IA nicardipine. Although the authors noted no angiographic dilatation when 0.5 mg of nicardipine was administered alone, the effect of combined therapy on the vessels is not known. Because of the lack of definitive effect of IA papaverine reported in the literature, we decided to use high-dose IA nicardipine as a treatment for vasospasm after SAH. Our hypothesis was that the administration of IA nicardipine at a dose higher than that previously reported results in angiographic dilatation and decreases transcranial Doppler TCD ; velocities without substantially increasing ICP or lowering blood pressure and pediatric.
Upon the analysis of innovative activities in the pharmaceutical industry under state socialism, Istvn Bihari draws the generalizable conclusion that the social and economic mechanisms generating innovation as a complex process do not work under the conditions of state socialism. "Consider an aquarium in which the fish die. As a first approach to the problem, we can introduce new fish in the aquarium. But if these die too i.e. `the product change' fails ; , we must recognize that the aquarium is a system in which the air supply, the temperature of the water, the limpidity, and other parameters all play a determining role in the survival of the fish. If any of the parameters differs from the limit values, the whole system breaks down. One of the gravest problems with socialist economy is that it focused on one single element of the complex system of management and innovation, and tried to improve it by issuing directives; these efforts, however, have always failed. Socialist economy was.
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Conjugated diene system 6, 7 and 8, 14 ; also lends itself to the formation of Diels-Alder adducts, which on further reaction may furnish various agonists such as etorphine a powerful veterinary analgesic sedative, being 5, 000-10, 000 more potent than morphine ; or various mixed agonist-antagonists such as buprenorphine 3, 10, 17 ; . Papaver bracteatum, a close relative to P. somniferum, contains principally thebaine about three percent ; , with only traces of codeine and no morphine. It was hoped that P. bracteatum could replace P. somniferum as a source of codeine, and thus lessen the demand for growth of the latter, but this has not materialized as being commercially viable 3, 10, 17 ; . PAPAVERINE Papaverine was first isolated from opium by Merck in 1848, and may still be isolated from opium after the extraction of morphine and codeine 11, 14, 17 ; . The elucidation of structure of the alkaloid was accomplished by Goldschmidt and others in the latter part of the nineteenth century, and was accomplished principally via a consideration of oxidation products. The alkaloid was first synthesized by Pictet and Gams in 1909, and as the amount of papaverine obtained from opium is small 0.5-1.5 percent ; , the synthetic route remains the source of this compound up to the present day 19 ; . Papaverine is a direct smooth muscle relaxant independent of muscle innervation, particularly if the muscle has been contracted due to vasospasm. The smooth musculature of the larger blood vessels is relaxed, including the coronary, systemic peripheral and pulmonary arteries. The resulting vasodilation has been potentially attributed to inhibition of cyclic nucleotide phosphodiesterases, with resulting increases in intracellular levels of cyclic AMP and cyclic GMP accompanied by decreases in Ca + The alkaloid also acts on the myocardium to depress conduction and irritability, as well as to prolong the myocardial refractory period 30-34, 38 ; . The compound is used therapeutically as its hydrochloride salt Pavabid Plateau Caps - Hoechst Marion Roussel; Pavagen TD -Rugby ; to obtain relief of cerebral and peripheral ischemia associated with arterial spasm and for symptomatic relief of myocardial ischemia complicated by arrhythmias 30-32 ; . The alkaloid also possesses Orphan Drug status because of its use as a topical gel in sexual dysfunction in order to obtain erection in patients with spinal cord injuries 35 ; . NOSCAPINE NARCOTINE ; Narcotine was probably isolated in 1803 or 1804 by the Parisian Derosne, either as a single substance or in admixture with morphine meconate 34, 36 ; . Other references cite its first isolation in 1817 by Robiquet 25 ; . The alkaloid is present in opium to the extent of 1-10 percent 14, 30, 33 ; , and belongs to the phthalideisoquinoline class of compounds. Its structure was obtained via a series of degradative reactions, including hydrolysis and reduction, and the stereochemisty at the chiral centers of - ; -narcotine was established via a series of degradative reactions and using optical rotatory dispersion techniques 39 ; . The alkaloid was found to be devoid of analgesic properties but to possess central antitussive activity equal to that of codeine. For that reason, the name of the compound was changed to noscapine. It has been speculated that the name noscapine was chosen because + - ; -narcotine was already known as "gnoscopine" at the time. Noscapine possesses bronchodilating and pegasys.
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Instituto de Investigacion Clinica, Universidad del Zulia, Maracaibo, Venezuela. The extracellular glycosaminoglycans in brains of different species were studied by light microscope histochemistry. Brains of rats, iguanas and pigeons were fixed with 1% glutaraldehyde-0.1 M phosphate buffer, pH 7.3, dehydrated through.
The pressure gradients measured in 1 6 the resting gradient was 19.8 mm Hg, the pressure gradient after papaverine The 99% confidence limits of the differtwo means were calculated using stanand were found to be 6.9 about the between the mean 18.8 ; , or 11.9 and are shown in figure 2. There is a highly and pegfilgrastim.
United States Department of Health and Human Services, Public Health Service, Office of the Surgeon General, "Women and Smoking: A Report of the Surgeon General, " Rockville, MD, U.S.D.H.H.S., 2001 United States Department of Health and Human Services, Public Health Service, Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, "Pregnant Substance-Using Women, Treatment Improvement Protocol TIP ; Series 2, " Rockville, MD, 1993 United States General Accounting Office, Report on Medicaid: "States Expand Coverage for Pregnant Women, Infants and Children, " August 1989 United States General Accounting Office, Report on Prenatal Care: "Early Success in Enrolling Women Made Eligible by Medicaid Expansions, " February 1991 United States National Institute of Child Health & Human Development, "Research on Preterm Labor and Premature Birth" Visintainer, P.F.; Uman, J.; Horgan, K.; Ibald, A.; Verma, U.; Tejani, N., "Reduced risk of low weight births among indigent women receiving care from nurse-midwives, " Journal of Epidemiology and Community Health, 54-233-238, March 2000 Wilcox, L.S; Koonin, L.M.; Adams, M.A., "Quality measures for unintended pregnancy in managed care: opportunities and challenges, " Women's Health, 9: 250-8, 1999 Wilkins, R.; Sherman, G, ; Best, P., "Birth outcomes and infant mortality by income in urban Canada" Canada Health Report, 3: 7-31, 1991 Zanata, R L., et al., "Effect of caries preventive measures directed to expectant mothers on caries experience in their children, " Braz. Dent. J. 14: 75-81, 2003 Zhang, X.; Miller, L.; Max, W.; Rice, D.P.; "Cost of smoking to the Medicare program, " Health Care Financing Review, Vol. 20, No. 4. 179-196, Summer 1999 and papaverine.
Patellofemoral Joint Problems in the Recreational Runners: The Mechanism, Examination and Conservative vs. Surgical Treatment Lower Extremity and Treatment Nuclear Medicine Injuries in Runners; The Prevention and pegvisomant.
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