LV average wall stress is dependent on wall thickness, local LV geometry, and chamber pressure. Although variations in wall stress occur throughout the cardiac cycle, the magnitudes of regional wall stresses at end diastole and end systole are probably maintained within narrow, well-defined physiological ranges. Perturbations in wall stress would therefore reflect the cumulative effect of alterations in any or all of these variables; the magnitude of the perturbation needed to disrupt normal stress patterns, however, remains unknown. Hood et al. 14 ; evaluated stress as an ``index of the `appropriateness' of the anatomic and functional responses to any given pressure or volume load'' without attempting to define the normal range of LV wall stress. In their study, biplane angiocardiographic data were used to derive mean LV wall stress using an axisymmetric model ; in both normal human hearts n 6 ; and hearts with a variety of pathological loading conditions. The authors demonstrated that, compared with normal controls, wall stress was generally in the normal range in patients with mitral stenosis, compensated LV volume overload, primary myocardial disease, and LVP overload. These findings are germane in that in each clinical situation, one or more of the variables that determine LV wall stress are presumably altered, but the myocardium appears to be able to adapt to these pathophysiological conditions. In hearts with hypertrophic myocardial disease, however, wall stress was significantly lower; in mixed pressure volume overload and decompensated LV volume overload, wall stress was significantly increased. The quest of Hood et al. 14 ; for an ``index of appropriateness'' in terms of.
Each year, the Audit Committee considers the process, results and developments of the risks identified. In addition, all elements of risk management are checked on an ongoing basis in the course of audits and optimized as and when necessary. Accounting and Controlling also adapt their reporting systems to changing conditions on a regular basis.
7.30am - 9.30am 8.45am - 4.00pm 7.00pm - 8.30pm The Wesley Research Institute breakfast Cardiology - clinical education sessions Healthwise World Diabetes Day public session.
LP procedures. A BMA is a diagnostic procedure that involves insertion of a needle into the bone, usually the ileac crest, and withdrawal of bone marrow fluid to assay for the presence or absence of cancer cells. An LP, similarly, is a diagnostic procedure in which a needle is inserted into the spinal column and spinal fluid is collected. Behavioral assessment research has shown that children and adolescents describe BMAs and LPs as very painful procedures McGrath, 1990 ; . The components of the comprehensive CBT protocol used by Jay et al. will be outlined further to illustrate an empirically supported treatment. These components include breathing exercises, imagery, filmed modeling, reinforcement incentive, and behavioral rehearsal. Breathing exercises were described as an activeattention diversion strategy. The goal was to help the child be active and learn a mastery over pain and anxiety rather than maintain a passive and submissive approach. A typical instruction involved having the child pretend to be a tire, breathing in to fill the tire with air, and then slowly breathing out, making a hissing sound as the air leaked out. This strategy was modeled and practiced by the child during preprocedure training. During the procedure, the psychologist and parent coached the child in use of the breathing skill. Imagery was conceptualized as a cognitive strategy. Emotive imagery as described by Lazarus and Abramowitz 1962 ; was the basis for this component of the package. Children were asked about their favorite super hero or cartoon character. A story was developed that included this imaginary character and involved the character helping the child cope with the painful medical procedure. The story often focused on imagining special powers and using help from the hero character to lie still and use breathing skills. In addition, imagery incompatible with the experience of pain e.g., a pleasant image of walking on the beach or going to an amusement park ; was taught to the child. As with breathing skills, imagery was created and practiced before the procedure. During the procedure the psychologist and parent prompted the child to use the individualized imagery scene emotive and or incompatible ; . Filmed modeling was included in the package. "Joy Gets a Bone Marrow and Spinal Tap" is a 12-minute film of a 6-year-old child with leukemia describing her thoughts and feelings about the medical procedures and demonstrating the use of coping skills. A coping model strategy was used and.
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METHOXYESTRADIOL 2ME2 ; IS a metabolite of 17 estradiol E2 ; that reportedly makes a minimal contribution to E2's hormonal actions 1 ; . This is based upon 2ME2's low circulating levels and its 2000-fold lower binding affinity than the parent compound ; for the estrogen receptor 2 ; . 2ME2 is derived from the O-methylation at the 2-position of 2-hydroxyestradiol, which is the major catechol estrogen produced by the cytochrome P450 system in the liver. Some of the unique physiological actions of estrogens may be the result of further conjugation of catechol estrogens by local enzymes in target tissues and cells. 2ME2 is recognized for its unique and profound actions on tumor cells, particularly for its inhibitory effects on angiogenesis and cell proliferation 37 ; . Because of its antiproliferative activity in established cancer cell lines, its tumorstatic actions in animal models for both primary and metastatic tumors, and its minimal toxicity, 2ME2 has been introduced into clinical phase I trials for the suppression of solid tumor growth. These actions of 2ME2 are not associated with E2 signaling pathways and appear selective for rapidly replicating tumor cells, although there are reports of its effects in normal cells 8 10 ; . Although 2ME2's mechanism of action remains uncertain, several reports have shown that it may induce apoptosis through p53 activation 11 ; , upregulate death receptor 5 12 ; , affect microtubule dynamics in vitro 13 ; , and inhibit the activity of superoxide dismutase 14 ; . More recently, 2ME2 has been shown to be toxic to MG63, TE85, and ROS cells but has no effect on the survival of primary osteoblasts 15 ; . These findings suggest that 2ME2 may be useful for treatment of osteosarcoma and stelazine
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Quality of life compared with placebo. Furthermore, no adverse effects of T patches were seen in women. Oral preparations of T are seldom used because of rapid metabolism and inactivation in the case of class A analogs, and liver toxicity in the case of class B and C analogs. However, oxandrolone, an orally active T derivative, may be suitable for treatment of HIV-associated wasting. Significant increases in weight and LBM in patients treated with oxandrolone have been demonstrated. In a 4-month randomized, placebo-controlled study of oxandrolone 15 mg d ; in 63 AIDS patients with more than 10% body weight loss, oxandrolone resulted in significant weight gain, increase in appetite, and improvement in physical activity 43 ; . At 16, patients taking oxandrolone had an increase of 0.6 kg in mean body weight, whereas the placebo patients lost 1.1 kg. In another study eugonadal HIV patients with weight loss were given T therapy at a dose of 100 mg wk and randomized to oxandrolone 20 mg d ; or placebo 44 ; . The patients in the oxandrolone group experienced increase in nitrogen retention, LBM, and muscle strength. Similarly, the use of nandrolone decanoate in this patient population also resulted in a significant increase in weight and LBM 45, 46 ; . Oxymetholone is another oral preparation that has been used to treat HIV wasting with positive effects on total body weight 47 ; . At dose of 50 mg three times a day, oxymethalone resulted in an increase of 8.2 kg over a 30-wk period, whereas the subjects on placebo lost 1.8 kg. There was also a significant improvement in the quality of life variables in subjects taking oxymethalone. In summary, these studies suggest that T and its analogs, regardless of the route of administration, result in an increase in weight and LBM. However, further studies would be welcomed to determine the exact nature of the relationship between factors such as dosage, route, and preparation used and the resultant changes in body composition in HIV patients, including women. Pulmonary disorders. As in HIV, weight loss in patients with chronic obstructive pulmonary disease COPD ; is associated with mortality 48 ; . Recent studies indicate a potential use for AAS therapy in COPD-associated wasting. A regimen of exercise, 250 mg im T administration at the baseline visit, and then 12 mg d oral stanozolol for 27 wk showed significant improvement in weight, body mass index, LBM, and muscle size compared with exercise alone in patients with COPD 49 ; . However, there was no increase in maximum inspiratory pressure or measures of physical endurance. Schols et al. 50 ; studied 217 patients with COPD and randomized them to either nandrolone decanoate plus nutrition and exercise or nutrition and exercise alone for a period of 8 wk. There was a significant increase in fat-free mass and an improvement in maximum inspiratory pressure in the nandrolone group. Similarly, oxandrolone therapy 20 mg d ; in tetraplegic patients produced significant improvement in weight and respiratory parameters 51 ; . Caution is recommended when treating COPD patients with androgens due to the risk of developing polycythemia. Further research in a large number of patients is needed before the use of AAS becomes routine in this patient population and suboxone.
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Supernova remnants are vital astrophysical objects because they create the Galactic cosmic rays, mix the heavy elements generated by supernovae into the interstellar medium, amplify Galactic magnetic fields, and dissipate mechanical energy into the surroundings. Many of these phenomena are necessary for controlling galactic structure and the creation of stars, planets, and life. Current radio observations of these properties are limited by instrumental sensitivity which results in faint, smooth-scale emission being missed. Often, the observations must be convolved to cover the emission over the entire area of fine-scale features in order to even detect them so they cannot be investigated in detail. The outstanding sensitivity and frequency agility of the SKA will allow great progress in understanding supernova remnants and their effects.
Table 2. Costs, Average Life Expectancy, and Incremental Cost-effectiveness of Influenza Strategies for Different-Aged Children During 2 Influenza Seasons and subutex.
Acceptable Test Groupings Approved Abbreviations in Parenthesis Complete Blood Examination FBC, FBE, CBE, CBP ; Haemoglobin Hb ; Haematocrit PCV ; Red Cell Count RBC ; Red Cell Indices Leucocyte Count WBC ; Platelet Count Differential Leucocyte Count Blood Film Examination Thalassaemia Haemoglobinopathy Screen Hb Red Cell Indices Hb Electrophoresis HbA2 HbF Quantification HbH Bodies Coagulation Screen COAG ; Includes: PT APTT Fibrinogen Platelet Count TCT Cross Matching Includes test for Rh and or other blood group antibodies. Bone Marrow Examination Please state if cytogenetics or markers are required. Marrow Booking: 07 ; 3840 4573 Suggested tests for common haematological disorders from which a selection may be made. These tests must be requested individually. Leukaemia Lymphoma FBC Bone Marrow Examination Cytogenetics Cell surface markers as indicated.
On Tuesday, December 18, 2007, the Nevada Athletic Commission requested the results of Joey Gilbert's hair test, and the October 5, 2007, drug test results. Mr. Gilbert's legal counsel and medical experts were waiting for the hearing before the Commission to present this evidence, but the Commission requested everything available to date, so we are complying. The test results to be provided to the Commission include polygraph test results. Shortly after Mr. Gilbert tested positive for steroids and methamphetamine, a Nevada Athletic Commission Inspector told Mr. Gilbert that if he didn't take the steroids and methamphetamine he should take a polygraph test to prove it--so he did. The test was administered on October 18th and 19th, 2007. The polygraph test was administered by Mr. Richard Putnam, a licensed polygraphic examiner in the State of Nevada. Putnam, a highly respected polygraphists in this State, was a full-time law enforcement polygraphic examiner in Washoe County for 16 years, and has practiced privately for the past 17 years. Putnam has conducted in excess of 4, 400 polygraphic examinations. Based on Mr. Putnam's analysis of the charts obtained during Mr. Gilbert's testing, he wrote in his report that it is his professional opinion that Joey Gilbert was "truthful" in answering the relevant questions in the negative, which included questions as to whether Mr. Gilbert had knowingly ingested steroids or methamphetamine. The charts were also evaluated using POLYSCORE, a computer polygraphic chart evaluation program developed by the Johns Hopkins University Applied Physics Laboratory, and also the Quantitative Evaluation System QuESt ; of the Layfayette Instrument Company--both of which produced consistent results with Mr. Putnam's opinion. Finally, Mr. Gilbert's charts were subjected to peer review by a polygraphic examiner for the Washoe County Public Defender's Office. The results of the review were also consistent with the opinion of Mr. Putnam. Mr. Gilbert and the Commission are currently waiting on University of Utah test results of the pre-fight B sample for steroids. Gilbert's pre-fight A sample tested positive for the steroid stanozolol following his September 12, fight in Reno. While we are hopeful that the test result comes back negative, we understand that there is a possibility that it may come back positive as a result of Mr. Gilbert unknowingly ingesting steroids. A study released this month Dec. 2007 ; , and reported on by USA TODAY, reported that 13 of the 52 supplements 25% ; purchased at various U.S. retailers contained different amounts of steroids. Additionally, six 11.5% ; of the supplements contained banned stimulants. Likewise, the New York Times reported in 2002 that a study commissioned and sudafed.
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Table 3. Characteristics of Patients and Their Association With the Risk of Suicidal Behavior.
LAWS AND PENALTIES FOR ANABOLIC STEROID ABUSE The Anabolic Steroids Control Act of 1990 placed anabolic steroids into Schedule III of the Controlled Substances Act CSA ; as of February 27, 1991. Under this legislation, anabolic steroids are defined as any drug or hormonal substance chemically and pharmacologically related to testosterone other than estrogens, progestins, and corticosteroids ; that promotes muscle growth. The possession or sale of anabolic steroids without a valid prescription is illegal. Simple possession of illicitly obtained anabolic steroids carries a maximum penalty of one year in prison and a minimum , 000 fine if this is an individual's first drug offense. The maximum penalty for trafficking is five years in prison and a fine of 0, 000 if this is the individual's first felony drug offense. If this is the second felony drug offense, the maximum period of imprisonment and the maximum fine both double. While the above listed penalties are for federal offenses, individual states have also implemented fines and penalties for illegal use of anabolic steroids. State executive offices have also recognized the seriousness of steroid abuse and other drugs of abuse in schools. For example, The State of Virginia enacted a new law that will allow student drug testing as a legitimate school drug prevention program. Some other states and individual school districts are considering implementing similar measures. The International Olympic Committee IOC ; , National Collegiate Athletic Association NCAA ; , and many professional sports leagues e.g. Major League Baseball, National Basketball Association, National Football League NFL ; , and National Hockey League ; have banned the use of steroids by athletes, both because of their potential dangerous side effects and because they give the user an unfair advantage. The IOC, NCAA, and NFL have also banned the use of steroid precursors e.g. androstenedione ; by athletes for the same reason steroids were banned. The IOC and professional sports leagues use urine testing to detect steroid use both in and out of competition. COMMON TYPES OF STEROIDS ABUSED The illicit anabolic steroid market includes steroids that are not commercially available in the U.S. as well as those which are available. Steroids that are commercially available in the U.S. include fluxoymesterone Halotestin ; , methyltestosterone, nandrolone Deca-Durabolin , Durabolin ; , oxandrolone Oxandrin ; , oxymetholone Anadrol ; , testosterone, and stanozolol Winstrol ; . Veterinary steroids that are commercially available in the U.S. include boldenone Equipoise ; , mibolerone, and trenbolone Revalor ; . Other steroids found on the illicit market that are not approved for use in the U.S. include ethylestrenol, methandriol, methenolone, and methandrostenolone. STEROID ALTERNATIVES A variety of non-steroid drugs are commonly found within the illicit anabolic steroid market. These substances are primarily used for one or more of the following reasons: 1 ; to serve as an alternative to anabolic steroids; 2 ; to alleviate short-term adverse effects associated with anabolic steroid use; or 3 ; to mask anabolic steroid use. Examples of drugs serving as alternatives to anabolic steroids include clenbuterol, human growth hormone, insulin, insulin-like growth factor, and gamma-hydroxybutyrate GHB ; . Examples of drugs used to treat the short-term adverse effects of anabolic steroid abuse are erythropoietin, human chorionic gonadotropin HCG ; , and tamoxifen. Also, diuretics and uricosuric agents may be used to mask steroid use. The following chart illustrates how masking is accomplished: Drug Group Uricosuric Agents Diuretics Epitestosterone Drug or Effect Probenecid Spironolactone, Furosemide Decreases Testosterone to Epitestosterone How drug masks steroid use Decreases entry of steroids into the urine Dilutes steroid concentration in the urine Reduces detection of testosterone usage and sulfadiazine.
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1st dam KATHIE'S SISTER, by Taylor's Falls. 4 wins at 3 and 4, , 095. Dam of 9 other foals of racing age, 8 to race, 6 winners, including-Kathie's Sibiling f. by Cutlass Fax ; . 6 wins, 2 to 6, 1, 710, 3rd Salem County S. MED, , 400 ; . Mr Peterson g. by Crusader Sword ; . 6 wins, 2 to 4, 3, 925. Kathie's Fax f. by Cutlass Fax ; . 2 wins at 4, , 227. Amazement g. by Holy Mountain ; . Winner at 2 and 3, , 200. 2nd dam AMAZING PLEASURE, by What a Pleasure. 2 wins at 3, , 830. Dam of 8 winners, including-ONLY A GLANCE f. by Proud Appeal ; . 3 wins at 3, , 532, Prima Donna S. [L] OP, , 040 ; , 2nd Artful S. [L], etc. Dam of-SALTY GLANCE g. by Salt Lake ; . 9 wins, 3 to 6, 7, 860, Iowa Sprint H. [L] PRM, , 000 ; , Tallahassee S. HIA, , 960 ; , etc. Glance's Gold. 3 wins to 3, , 290. Dam of GOLDEN REMARK f. by Regal Remark ; 10 wins, 5, 021, City of Edmonton Distaff H. [L], NP, , 500, etc.; CRESCENT REMARK g. by Regal Remark ; to 6, 2005, 7, 446 & , 298-CAN, Canadian Juvenile S. [L], etc. Proud Caitlin f. by Proud Appeal ; . 4 wins at 2 and 3, , 815, 2nd Yearling Sales S. [LR] WO, , 000 ; . Dam of 6 winners, including-DEVILISH ERICA f. by Devil's Bag ; . Winner at 2 and 3, , 996, City of Hialeah S. [L] HIA, , 960 ; . Hunters Circle f. by Trempolino ; . 2 wins at 3, , 767, 3rd Channel Three S.-R PHA, , 019 ; . Producer. Hadley's Boy c. by Text ; . 5 wins at 2 and 3, , 316, 2nd Bachelor S. [L] OP, , 920 ; , Second Pleasure S. OP, , 840 ; , etc. 3rd dam AUDACE, by Tom Fool. Winner at 3, , 150. Half-sister to PROUD POCKET 4, 261, sire ; , BOLD THRUST, MIDNIGHT TRAVELER. Dam of 5 winners. Granddam of Quick Casting 5, 655 ; , Earplug 9, 929 ; , Shameful Nobility dam of Dixie of Perth, 0, 416; Forecastor, at 3, 2005 ; , Yashima Captain in Japan ; , Dr. Barth. Engagements: Louisiana Futurity. Accredited Louisiana-bred.
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DME and Home Health services requests must have a Practitioner's order on initial requests and extensions. At the time of the request for prior authorization, the Certification of Medical Necessity CMN ; and or Practitioner order for DME HH O & P must be available and can be faxed or phoned in to BlueCare. It needs to include the Practitioner order and date of order. * Out-of-Network telephone requests are only accepted if the Member needs to be seen by an out-ofnetwork Physician on an urgent emergent basis or the Member is being sent directly from the PCP's office to the specialist on the same day. Requests for initial inpatient admissions, outpatient surgery, 23-hour observation, Global High Risk OB, and Specialty Pharmacy eff. 10 06 ; can be submitted electronically via e-Health Services. This service allows you to submit requests to BlueCross BlueShield of Tennessee online in a real-time web secured environment and receive online approvals. If the notification prior authorization request meets specific criteria, you will receive an online approval and a reference number. Your request will be recorded in our computer system as it is received. Note: Skilled nursing and inpatient rehabilitation requests submitted online will pend into our system. Our internal staff will retrieve the requests and continue to handle with the current authorization process. To access e-Health Services, click on the Providers tab in the e-Health Services section on the company Web site, bcbst . This service is available 24-hours-a-day, 7-days-a-week for all registered providers. If you have not yet tried any of the services offered via BlueAccess, you can register online. From our home page on bcbst , click on the "Register" button in the "BlueAccess" section in the top right corner of the page. You will then follow the simple registration instructions to order your "shared secret" that you will use to gain access to the secure area of our Web site. Within 2 business days of registering, your shared secret will be mailed to you. While online, try out all of the services offered via BlueAccess and stanozolol.
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The MRP family of efflux transport proteins is known to confer multidrug resistance to a variety of structurally unrelated compounds Borst et al., 1999 ; . The expression of these proteins in the brain has recently been examined within the blood-brain and blood-cerebrospinal fluid barriers Wijnholds et al., 2000; Zhang et al., 2000 ; . Multiple MRP homologs are expressed within these barriers and seem to contribute to the low brain penetration of a variety of therapeutic compounds, including antiretroviral drugs used in the treatment of HIV-1 Miller et al., 2000 ; . The primary cells infected by HIV-1 in the brain are microglia brain macrophages ; Bagasra et al., 1996; Epstein, 1998 ; but little is known about expression of MRP family members in microglia. The presence of rMRP1 transcripts in cultured rat microglia was recently reported Ballerini et al., 2002; Hirrlinger et al., 2002 however, protein levels and functional activity of rMRP1 were not extensively examined. The present study investigates the expression of rMRP1 in a rat microglia cell line MLS-9 ; at both the protein and functional levels. We had previously found rMRP1 transcripts in primary rat microglia but did not detect them in MLS-9 cells using primers that recognize a region in the 3 end of the rat gene Lee et al., 2001b ; . In the present study, we amplified a region in the middle of the gene from primary microglia and from MLS-9 cells and obtained a single band for each cell type. Each product was the expected size, and sequencing confirmed they were both rMRP1. Western blotting using the monoclonal antibody MRPr1 confirmed the expression of rMRP1 protein in primary cultures of rat microglia and the MLS-9 microglia cell line. This antibody recognizes hMRP1 and rMRP1 Rao et al., 1999 ; and does not cross-react with MRP2 6 Hipfner et al., 1998 ; . A more robust rMRP1 band was detected in primary cultures of rat microglia than in MLS-9 cells, possibly due to differences in protein processing or down-regulation of rMRP1 in the cell line. A similar dis and sulfinpyrazone.
We acknowledge Sankyo, Eisai, Otsuka Pharmaceutical, and Banyu Pharmaceutical for providing pravastatin, E3040 and E-glu, GPFX and GPFXG, and BQ-123, respectively. This work was supported in part by a Grant-in-Aid for Scientific Research provided by the Ministry of Education, Science, and Culture of Japan, in part by a grant for Cancer Research from the Ministry of Health and Welfare of Japan, and in part by CREST, Japan Science and Technology Corporation. Address for reprint requests and other correspondence: Y. Sugiyama, Graduate School of Pharmaceutical Sciences, Univ. of Tokyo, 731, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan E-mail: sugiyama seizai.f.u-tokyo.ac.jp ; . Received 3 April 1998; accepted in final form 6 January 1999. REFERENCES 1. Anderson, M. P., R. J. Gregory, S. Thompson, D. W. Souza, S. Paul, R. C. Mulligan, A. E. Smith, and M. J. Welsh. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science 253: 202205, 1991. Barouki, R., M. Chobert, J. Finidori, M. Aggerbeck, B. Nalpas, and J. Hanoune. Ethanol effects in a rat hepatoma cell line: induction of -glutamyltransferase. Hepatology 3: 323329, 1983. Bissig, M., B. Hagenbuch, B. Stieger, T. Koller, and P. J. Meier. Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes. J. Biol. Chem. 269: 3017 3021, Bohme, M., M. Muller., I. Leier., G. Jedlitschky., and D. Keppler. Cholestasis caused by inhibition of the adenosine.
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Ne week they recommend one diet--the next week they recommend another!" "I guess I can just eat whatever I want!" These were the comments of the day when the low-fat dietary pattern and risk of cardiovascular disease CVD ; results of the Women's Health Initiative WHI ; Dietary Modification Trial were announced in February DOC News, March 2006 ; , with the following conclusions: Over a mean of 8.1 years, a dietary intervention that reduced total fat intake and increased intakes of vegetables, fruits, and grains did not significantly reduce the risk of CHD [coronary heart disease], stroke, or CVD in postmenopausal women and achieved only modest effects on CVD risk factors, suggesting that more focused diet and lifestyle interventions may be needed to improve risk factors and reduce CVD risk.1 and stelazine.
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