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Armand, G., Balazs, E.A., Meyer, K., and Reyes, M. 1983 ; Isolation and characterization of ichthyosan from tuna vitreous. Connect. Tissue Res., 11, 2133. Kennedy, J.F., Phillips, G.O., and Williams, P.A., eds. 2002 ; Hyaluronan: volume 1: chemical, biochemical and biological aspects. Woodhead Publishing, Cambridge, UK. Linker, A. and Meyer, K. 1954 ; Production of unsaturated uronides by bacterial hyaluronidases. Nature, 174, 11921193.
Method: NAT-2001-00102 LOD LOQ: 1.0 Micrograms Instrument Detector: HIGH PRESSURE LIQUID CHROMATOGRAPHY - UV VIS DETECTOR Media: [SW1] - WIPE - PRE-WETTED CELLULOSE FILTER MATERIAL Shelf Life: 1 Year Flow Rate: N A Rec. Vol. or Time: Wipe 100 Square cm Interferences: Any compound which has the same retention time under the prescribed conditions and absorbs or emits light in the spectral area of interest are potential interferences. Compatibility Indicator: None Shipping Handling: None Method: NAT-2001-00102 LOD LOQ: 1.0 Micrograms Instrument Detector: HIGH PRESSURE LIQUID CHROMATOGRAPHY - UV VIS DETECTOR Media: [TX76] - ALPHA SWAB WITH 6 INCH HANDLE AND GLASS VIAL Shelf Life: 1 Year Flow Rate: N A Rec. Vol. or Time: Sufficient volume to achieve desired LOQ based on analytical sensitivity. Call Lab. Interferences: Any compound which has the same retention time under the prescribed conditions and absorbs or emits light in the spectral area of interest are potential interferences. Compatibility Indicator: None Shipping Handling: None.
Once a patient is initiated on ART there may be various reasons to change current ART. Many studies have documented that at 1 year after initiating ART 40-50% patients had actually changed their first line regimen for various reasons.130, 131 Changing ART can be broadly classified into 2 groups: Substitution Replacing a single dual ARV drug by another in a regimen is referred to as substitution. There are various indications for substitution; l Toxicity: Substituting a safer ARV drug for an offending agent e.g. TDF or ABC or ZDV for d4T peripheral neuropathy, lipoatrophy, symptomatic hyperlactetemia ; , 132, 133 TDF or ABC or d4T for ZDV anemia, GI intolerance ; . l Simplification: Substituting for simplifying a complex regimen either for reducing pill burden or simpler scheduling e.g. bid to qd drugs TDF for ZDV, ATV r for other PI r ; l Cost: Substituting a single agent for reducing cost of the regimen e.g. NVP for EFV especially after TB treatment ; l Proactive: Substituting TDF or ABC for thymidine analogs ZDV, d4T ; anticipating long term adverse events. l Pregnancy: Substituting ZDV for other NRTI and NVP for EFV in for preventing MTCT and avoiding teratogenicity. l Drug-drug interaction: e.g. Patient on NVP based regimen developing TB shifted to an EFV based regimen maintaining the same nucleoside backbones
Can deal with. Here is our chance to contribute to public health in a way that the medical establishment can't. We won't get rich doing this. The programs that would hire us to supervise are under-funded and overworked. But they are staffed mostly with people who are genuinely concerned about their clients and will be respectful and grateful for the help we give them, if we're willing to give it. Like the clients, the staffs of these programs are people who don't think of acupuncture or Oriental medicine as having anything to do with them--they can't afford private treatment, and they don't know anybody who does acupuncture. It's just not part of their world. Yet. The Association intends to set up a NADA National Acupuncture Detoxification Association ; training later this year, and make the training available to members for as little as will cover the costs so that anyone who might be interested in becoming a supervisor can get qualified. Here are some drawbacks to being a supervisor: If we take on the job, we have to be there when we say we will, every time. The clients mostly haven't had reliable people in their lives; they don't expect it, and their attitudes are often not welcoming initially. We will have to drive long distances to rural areas. We will be dealing with people who have no understanding of what we do, or interest in finding out -at least, not until they begin to see the benefits. We'll need to register with the BOAM annually and pay them an administrative fee. We'll be treating people amazed at.
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Reaction, any 300.11 Converter, tuberculosis test reaction ; 795.5 Convulsions idiopathic ; 780.39 apoplectiform see also Disease, cerebrovascular, acute ; 436 brain 780.39 cerebral 780.39 cerebrospinal 780.39 due to trauma NEC - see Injury, intracranial eclamptic see also Eclampsia ; 780.39 epileptic see also Epilepsy ; 345.9 epileptiform see also Seizure, epileptiform ; 780.39 epileptoid see also Seizure, epileptiform ; 780.39 ether anesthetic correct substance properly administered 780.39 overdose or wrong substance given 968.2 other specified type - see Table of Drugs and Chemicals febrile 780.31 generalized 780.39 hysterical 300.11 infantile 780.39 epilepsy - see Epilepsy internal 780.39 jacksonian see also Epilepsy ; 345.5 myoclonic 333.2 newborn 779.0 paretic 094.1 pregnancy nephritic ; uremic ; - see Eclampsia, pregnancy psychomotor see also Epilepsy ; 345.4 puerperal, postpartum - see Eclampsia, pregnancy recurrent 780.39 epileptic - see Epilepsy reflex 781.0 repetitive 780.39 epileptic - see Epilepsy salaam see also Epilepsy ; 345.6 scarlatinal 034.1 spasmodic 780.39 tetanus, tetanic see also Tetanus ; 037 thymic 254.8 uncinate 780.39 uremic 586 Convulsive - see also Convulsions disorder or state 780.39 epileptic - see Epilepsy equivalent, abdominal see also Epilepsy ; 345.5 Cooke-Apert-Gallais syndrome adrenogenital ; 255.2 Cooley's anemia erythroblastic ; 282.4 Coolie itch 126.9 Cooper's disease 610.1 hernia - see Hernia, Cooper's Coordination disturbance 781.3 Copper wire arteries, retina 362.13 Copra itch 133.8 Coprolith 560.39.
1. Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2 positive breast cancer N Engl J Med: 2005; 353: 1659-72 Lan KKG, DeMets DL. Discrete sequential boundaries for clinical trials. Biometrika: 1983: 70: 659-63 Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2 overexpressing metastic breast cancer. J Clin Oncol. 2002; 20: 719-26 Baselga J, Carbonell X, Castaneda-Soto NJ, et al. Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. Clin Oncol. 2005; 23: 2162-71 Pocock SJ, Simon R. Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trail. Biometrics. 1975; 31: 103-15 Medicines Information National Prescribing Centre Prescribing Outlook September 2005. Pipeline Drugs Trastuzumab inj; page 15. 7. Herceptin Summary of Product Characteristics; Roche Products Limited. Accessed emc.medicines 31 10 2005 Romond HE, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive beast cancer N Engl J Med: 2005; 353: 1673-84 Bendell JC, Domcheck SM, Burtsein HJ, et al. Central nervous system metastases in women who received trastuzumab-based therapy for metastatic breast carcinoma Cancer. 2003; 97: 2972-7 Clayton AJ, Danson S, Jolly S, et al. Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer. Br J Cancer. 2004; 91: 639-43 Paik S, Bryant J, Tan-Chiu E, et al. Real-world performance of HER2 testing--National Surgical Adjuvant Breast and Bowel Project experience. J Natl Cancer Inst. 2002; 94: 852-4 and faslodex.
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From the parallel behavior of how come and factive predicates, I have argued that how come is factive, while why and other wh-phrases are not. The parallel behavior of factives and how come, as opposed to other wh-phrases, is summarized in table 24 ; along with the facts from section 3.1 regarding rhetorical questions.
The clinical success rates for each of these three trials were as follows: factive 5 days 320 mg ; : 8 2 % levofloxacin 7 days 500 mg ; : 8 1 % factive 5 days 320 mg ; : 8 0 % clarithromycin 7 days 500 mg bid ; : 8 % factive 5 days 320 mg ; : 9 6 % amoxicillin clavulanate 7 days 500 mg 125 mg, 3 times day, or tid ; : 9 2 % factive was also studied for the treatment of community-acquired pneumonia in three double-blind, randomized, active-controlled clinical studies, one open, active-controlled study, and two uncontrolled studies and felbamate.
Our packing list is at the end of this guide. Basically, we packed clothing for the 3 of us one suitcase, packed baby supplies and Jin's clothing in the second suitcase, and each of us carried a backpack. Shao and I also wore fanny packs. She kept tissues, lip balm, a mini flashlight, and other tiny treasures in hers. When we arrived at our destination, we used one of our backpacks as a diaper bag for the girls on our daily excursions, and used the other backpack to carry our cameras, camcorder, umbrellas, and the documents needed for appointments. [EMK Press note: It's useful to carry enough diapers, wipes and a complete change of clothing for each child onto the aircraft. It's a necessity also to carry bibs either wipeable pack-able ones or disposable ; . In a confined space like an airplane, it's amazing what children can do with food and where it goes! ; . These bibs, clothes, and diapers, can be slipped in backpacks with the toys] Check the climate of your destination before deciding on the clothing to pack. Our two weeks were spent in a very warm climate, making packing very simple! My husband and I packed 4-5 mix & match outfits each. For Shao, I chose 6 play outfits, then put each top bottom socks matching hair accessories in a gallon Ziploc bag. That way, her clothing was organized and ready to go. We used local or hotel laundry services every few days. I also took a couple of her dresses for the adoption registration appointment and dinner at a nice restaurant. She wore one pair of sneakers for most of the trip and we packed a pair of sandals to go with the dresses or use as back-up shoes. Also, be sure to pack a sun hat for your toddler or preschooler if you will spend any part of your trip in a warm, sunny climate. We packed 3 sets of toys activities for Shao: one set for the flight over, one set for the stay in China also knowing we would buy her some toys in there ; , and one set for the flight home. This way, the same toys didn't lose their appeal. We packed the first set in her backpack, along with several snacks: Goldfish, fruit snacks, mini M & Ms in case we really needed to bribe her ! ; , raisins, juice boxes. We took an empty mini water bottle with a pop-top sipper in case she ran out of juice boxes and needed a refill from the flight attendant. And she was allowed to bring one favorite stuffed animal, along with the favorite panda blanket. Every child is different, so the toys that worked for Shao might not work for your child. But without question, her favorite item for the flights was a set of Play-do mini cans sold in the party favor section of stores ; and Play-do "cookie cutters" to make shapes. She was entertained for long stretches at a time, flipping down the tray table and making shapes. Sticker books were another hit, as were lacing cards which we only gave her on the.
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Consciousness that will bring us our true Continued from page 6 desires and this takes serious dedication. When Q. Does a person ever really change or is it the pain of staying the same is more than the just pretending? Shauna, Bakersfield ; pain of change then one can change. Like with A. It seems that change is impossible Libra it all hangs in the balance of the scales sometimes. But so few understand that change and ultimately in the letting go. must come from within. We must change our thinking and then the world, which is "our ~ Please send in those questions. Mahalo and world", "our consciousness", will express itself aloha nui loa, R.K. as our thinking is then being expressed. Willpower has its place in life. Just as does the ego and the conscious mind play a role in the final outcome of our development. We must get to the door through which we pass and complete that change in consciousness that alters circumstances in our life. Often that requires willpower and a stubbornness of desire to have things be different. But too often the change is misunderstood. It is in the changing of our and fennel.
Smoking is a risk factor or a triggering agent in numerous skin diseases, including psoriasis Mills et al. 1992, Naldi et al. 1992, Poikolainen et al. 1994 ; , infectious eczematous dermatitis and vesicular palmar eczema Karvonen et al. 1992, Edman 1988 ; . Men suffering from infectious eczematous dermatitis have been found to smoke more than controls both before and during the disease Karvonen et al. 1992 ; . Heavy smoking is also associated with the onset and exacerbation of pustulosis palmoplantaris, Eriksson et al. 1998 ; and a larger proportion of patients suffering from hidradenitis suppurativa are smokers 89 percent ; compared to patients with other dermatological diseases 46 percent ; Konig et al.1999 ; . Smoking may also affect the efficacy of treatments on skin diseases. A decreased response to bath-PUVA treatment of palmoplantar eczema has been reported among patients who smoke Douwes et al. 2000 ; . According to an American.
Being complied. For HIV AIDS and antitrafficking subcomponent along EW corridor to be financed by ADB $ 400, 000 ; .Recruitment of 4 NGOs and 3 local consultants started, advertisement published on 6 June 2005. Screening process for shortlisting candidates is in progress and fenoprofen.
Antigens without ill effects for diseases to which they are immune.4, 38 Consideration of reactogenicity must be balanced with the beneficial vaccine effects when inactivated vaccines are administered. However, most clinical experience suggests these reactions to be very low.38 tHimerosal PreserVatiVes Thimerosal is a mercury-containing compound that has been used as a preservative in biologicals and vaccines since the 1930s. Given the widely acknowledged value of reducing exposure to mercury, a possible link between thimerosal and autism and the precautionary recommendations of ACIP and AAP, vaccine manufacturers, the FDA and other Public Health Service agencies are collaborating to reduce the thimerosal content of vaccines or to replace them with formulations that do not contain thimerosal as a preservative as quickly as possible without causing unnecessary disruptions in the vaccine supply system.39, 40 Past evidence has suggested that the risk, if any, to infants from thimerosal exposure is slight and the risks for not vaccinating children far outweigh the theoretical risk for exposure to thimerosal-containing vaccines during the first six months of life. A 2004 report from the Institute of Medicine IOM ; concluded that there is no association between autism and vaccines that contain thimerosal as a preservative.20 Even so, much progress has been made, to date, in removing or reducing thimerosal in vaccines. Presently, all vaccines except inactivated influenza ; routinely recommended for infants in the United States are available only as thimerosal-free formulations or containing only trace amounts. Inactivated influenza vaccine still is available in a formulation that contains thimerosal, but also is available as thimerosal-free and containing trace amounts.20 timing and sPacing of Vaccines Issues often encountered in clinical practice include timing of antibodycontaining blood products e.g immune globulin ; , live vaccines most important.
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P27 Proprotein Convertase Subtilisin kexin type 9 PCSK9, Narc-1 ; is a new gene involved in familial Characterization of High Density Lipoprotein Particles Formed by hypercholesterolemia. Our group showed that patients heterozygote for the S127R mutation ATP-Binding Cassette Transporter A1-Mediated Efflux of Cellular Lipids to develop hypercholesterolemia and an increased production of apoB containing lipoparticles. Apolipoprotein A-I Others showed that hepatic PCSK9 affects the amount of Low Density Lipoprotein receptors at the cell surface LDLr ; . Wild-type PCSK9 therefore appears to regulate plasma clearance of Phu T Duong, Heidi L Collins, Margaret Nickel, Sissel Lund-Katz, George H Rothblat, atherogenic particles. In an effort to assess a potential role of PCSK9 in the metabolic Michael C Phillips; The Children's Hosp of Philadelphia, Univ of Pennsylvania Sch of syndrome, we studied the regulation of PCSK9 by insulin and glucose. In vivo studies suggested Medicine, Philadelphia, PA a combined influence of glucose and insulin on PCSK9 expression. Real time Q-PCR analysis revealed that PCSK9 expression increases with age in ZDF fatty diabetic rats 2-fold increase The purpose of the study is to characterize the nascent high density lipoprotein HDL ; particles in 10 and 20 weeks old compared to lean ZDF rats or ZDF fatty rats of 6 weeks old, p 0, 05, formed by interaction of human plasma apolipoprotein apo ; A-I with J774 mouse macrophages student test ; . In rats treated with streptozotocin, PCSK9 mRNA levels dropped by two fold in which the ATP-binding cassette transporter A1 ABCA1 ; is up-regulated. Non-denaturing p 0, 05 ; , and insulin injections partially restored it. In mice exposed to a 24h starving period two-dimensional gradient polyacrylamide gel electrophoresis shows that 3 sizes of apo a dramatic decrease in PCSK9 mRNA and protein was observed which returned to normal A-I-containing HDL particles are formed; these particles exhibit alpha-electrophoretic mobility. within 24h after re-feeding. In vitro, glucose dose dependently increased PCSK9 mRNA levels The results of chemical cross-linking using bis sulfosuccinimidyl ; suberate and SDS-PAGE in HepG2 cells, in the absence of insulin 2.5 fold increase between 5 and 10mM after 24h show that apo A-I is the sole protein and that the 9 nm particles contain 2 apo A-I molecules treatment, p 0, 05, ; . In immortalized human hepatocytes IHH ; , a 15h exposure to 25nM whereas the 12 nm particles contain 3 4 apo A-I molecules. Far-ultraviolet circular dichroism insulin increased PCSK9 mRNA levels by 4 fold compared to cells cultured without insulin data indicate that the apo A-I alpha-helix contents are about 50% in both cases. The ratio of p 0, 05 ; primary cultures of mouse hepatocytes, an 18h period exposure to 100nM insulin phospholipid PL ; apo A-I is 96 1 and 196 1 mol mol ; for the 9 and 12 nm particles, increased 2 fold PCSK9 mRNA levels, at low 5mM ; or high doses of glucose 25mM ; p 0, 05 ; respectively. The PL compositions of both particles are similar: 20 24% phosphatidylcholine . Together these results show that PCSK9 is activated by glucose and insulin. Although the PC ; , 47 40% phosphatidylethanolamine PE ; and phosphatidylserine PS ; , 9 8% phosphatimolecular mechanisms are still under investigation, this suggests that PCSK9 could play a role dylinositol PI ; , 9 13% sphingomyelin SM ; , 8 10% lyso PC, 75% free fatty acid FA ; . The in the development of dyslipidemia associated with alterations of glucose homeostasis, as Downloaded from atvb.ahajournals by onand negative charge on these HDL particles can be explained by the presence alpha-mobility March 14, 2008 found in patients with the metabolic syndrome and diabetes. Abstracts are embargoed until time of presentation and fenugreek.
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This study was conducted in collaboration with Harvard Vanguard Medical Associates, a health care delivery system composed of 14 multispecialty medical group practices that serve more than 270 000 patients. The 10 health centers that were invited to participate took part in the study.
Rosen DS. Management of Mental Illness in Primary Care Practice: Part 1. Adolescent Health Update. 2005: 17 3 ; : 1-8. SAMHSA, National Mental Health Information Center. Major Depression in Children and Adolescents. 2003, : mentalhealth.samhsa.gov publications allpubs CA-0011 default National Mental Health Association. Adolescent Depression: Helping Depressed Teens. : nmha index ?objectid 4 Moskos MA et al. Adolescent Suicide Myths in the United States. Crisis. 2004; 25 4 ; : 179. 5 National Institute of Mental Health. NIMH-Funded National Comorbidity Survey Replication Study: Mental Illness Exacts Heavy Toll Beginning in Youth. 2005, : nimh.nih.gov healthinformation ncs-r 6 US Department of Education. Twenty-fifth Annual Report to Congress on the Implementation of the Individuals with Disabilities Education Act, 2003; 1 ; . 7 Monitoring the Future. Trends in Lifetime Prevalence of Use of Various Drugs for Eighth, Tenth, and Twelfth Graders. 2005, : monitoringthefuture data 05data pr05t1 8 US Public Health Service, Reports of the Surgeon General. Mental Health: A Report of the Surgeon General. 1999, : surgeongeneral.gov library mentalhealth home 9 National Highway Traffic Safety Administration. Traffic Safety Facts: A Compilation of Motor Vehicle Crash Data from the Fatality Analysis Reporting System and the General Estimates System. 2004, : nhtsa.dot.gov 10 American Lung Association, Epidemiology and Statistics Unit Research and Program Services. Trends in Tobacco Use. 2006, : lungusa site apps s content ?c dvLUK9O0E&b 34706&ct 67648 and ferret.
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Bleeding. The incidence of major and minor bleeding episodes is shown in Table 3. Bleeding rates were low, and no significant differences between the treatment groups were observed. No major bleeding episodes occurred in patients receiving 2.5 mg fondaparinux or enoxaparin. Pharmacokinetics. A dose-dependent increase was observed in both the predose and post-dose fondaparinux plasma concentrations determined on day 3 of treatment. The mean post-dose concentrations were 0.41, 0.65, 1.15, and 1.61 mg l for patients receiving 2.5, 4, 8, and 12 mg fondaparinux, respectively. Within each dosage group, the fondaparinux plasma concentrations in patients with a primary end point were similar to those of patients without death, MI, or recurrent ischemia. Similarly, no significant differences were observed in fondaparinux plasma concentrations between patients with and those without bleeding. As expected, there was considerable overlap in plasma concentrations among the four dosage groups. When patients were regrouped according to the post-dose plasma concentration at day 3, the lowest rates of death, MI, or recurrent ischemia were observed for patients with plasma concentrations in the lowest range, whereas no correlation with plasma concentration was observed for bleeding events.
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QUINOLONES AND BLOOD GLUCOSE ABNORMALITIES HYPOGLYCEMIA, HYPERGLYCEMIA ; Dysregulation of blood glucose has been noted with all the available fluoroquinolones ie, ciprofloxacin [Cipro], gatifloxacin [Tequin], gemifloxacin [Factive], levofloxacin [Levaquin], lomefloxacin [Maxaquin], moxifloxacin [Avelox], norfloxacin [Noroxin], ofloxacin [Floxin] ; , including some fatalities. Hyperglycemia has been reported with all the available fluoroquinolones. Hypoglycemia has also been reported with every agent but gemifloxacin Factive ; , the newest agent. The quinolones increase insulin release from pancreatic islet cells as a class, therefore caution may be warranted with all quinolone antibiotics. Based on postmarketing data, disturbances in blood glucose may be more common with gatifloxacin than with other fluoroquinolones. The FDA and Bristol-Myers Squibb are revising the gatifloxacin product labeling to reflect this increased risk. Gatifloxacin will be contraindicated in diabetic patients when the changes are finalized. Other changes to the product labeling include additional information about risk factors for blood glucose abnormalities and additional monitoring recommendations. Risk may be increased in patients receiving concomitant therapy with hypoglycemic agents, elderly patients, or patients with renal dysfunction and faslodex.
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Nordic Journal of African Studies 50 ; .equivalent laffice sites, so there is no reason why change should be transferred between them. Consequently, in a static diamond . 51 ; There seems to be no particular reason why he should propose solutions to the question he implies about the use of. 52 ; It is puzzling why Jeffreys should choose to appear in a court of York. 53 ; .tallations Inspectorate that it sees no reason why the PWR should not receive a licence for construction and operation in the UK. Factivity and root should: Root should normally refers to an event in the future. Future time reference is subtly bound up with modality, and it is an essential component of personal directives Lyons 1977: 745 ; , including commands, requests, warnings, recommendations, and exhortations. One of the felicity conditions for making such a directive is that the speaker believes that the action or state referred to in the main verb has not yet been done or achieved. Thus, in such examples, the writer is referring to something which has not happened or is not happening, but which, if the writer's opinion is taken, will happen in the future. Futurity is inevitably linked with non-factivity. A non-factive statement is one in which the writer is not committed to either the truth or the falsehood of the proposition expressed in the main predication. Since the future is by definition unknown, and since a speaker or writer cannot assert either the truth or the falsity of what is still unknown, then statements with future time reference are nonfactive. Factive should in the CCE and LOB corpus occurs in quite different contexts. For example, in the LOB and Birmingham corpora, Coates 1983 ; and Johns 1991 ; report that factive should is frequent, occurring mostly in the context of "that-clauses" evaluated with adjectives such as "appropriate" or with any evaluative predicative. Examples 54 ; and 55 ; from the British corpora are those of evaluated "that-clauses". 54 ; It is surprising that there should be this relationship. 55 ; It is strange that birds should want to increase their active sleep. These contexts are extremely rare in the CCE. However, there are cases of factive should in the CCE in a different context that is, the "IT should BE + V-ED + THAT." contexts: 56 ; .order of valour and order of merit. It should be noted that, the latter part of the ceremony was intense. OP 136 ; 57 ; .Muslims have increased to 1.200. It should be noted that Fundung Sub-division has a large Muslim population. OP 139 ; 58 ; .that victims are arrested. It should be noted that Mrs Joyce is a pregnant woman. OP 142 ; 59 ; .their Chairman also mentioned. It should be recalled that last year's National Assembly was. OP 147 ; Fifthteen cases of factive should is found in this context in the CCE. The following are the frequencies of the various patterns found in the sample.
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