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Chen, S.U., Shieh, J.Y., Wang, Y.H. et al. 1998 ; Pregnancy achieved by intracytoplasmic sperm injection using cryopreserved vasal-epididymal sperm from a man with spinal cord injury. Arch. Phys. Med. Rehabil., 79, 218221. Chung, P.H., Yeko, T.R., Mayer, J.C. et al. 1995 ; Assisted fertility using electroejaculation in men with spinal cord injury a review of literature. Fertil. Steril., 64, 19. Chung, P.H., Verkauf, B.S., Eichberg, R.D. et al. 1996 ; Electroejaculation and assisted reproductive techniques for anejaculatory infertility. Obstet. Gynecol., 87, 2226. Chung, P.H., Verkauf, B.S., Mola, R. et al. 1997 ; Correlation between semen parameters of electroejaculates and achieving pregnancy by intrauterine insemination. Fertil. Steril., 67, 129132. Chung, P.H., Palermo, G., Schlegel, P.N. et al. 1998 ; The use of intracytoplasmic sperm injection with electroejaculates from anejaculatory men. Hum. Reprod., 13, 18541858. Colpi, G.M., Sommadossi, L. and Zanollo, A. 1983 ; Infertility caused by retrograde ejaculation: a successfully treated case. Andrologia, 15, 592594. Comarr, A.E. 1970 ; Sexual function in patients with spinal cord injury. Urol. Int., 25, 134168. Comarr, A.E. and Downey, C.A. 1985 ; Sexuality and fertility among spinal cord and or cauda equina injuries. J. Am. Paraplegia Soc., 8, 6775. Crich, J.P. and Jequier, A.M. 1978 ; Infertility in men with retrograde ejaculation: the action of urine on sperm motility, and a simple method for achieving antegrade ejaculation. Fertil. Steril., 30, 572576. Dahlberg, A. and Hovatta, O. 1989 ; Anejaculation following spinal cord injury does not induce sperm-agglutinating antibodies. Int. J. Androl., 12, 1721. Dahlberg, A., Ruutu, M. and Hovatta, O. 1995 ; Pregnancy results from a vibrator application, electroejaculation, and a vas aspiration programme in spinal-cord injured men. Hum. Reprod., 10, 23052307. David, A., Ohry, A. and Rozin, R. 1977 ; Spinal cord injuries: male infertility aspects. Paraplegia, 15, 1114. Dees, J.E. 1949 ; Congenital epispadias with incontinence. J. Urol., 41, 513522. Denil, J., Ohl, D.A., Menge, A.C. et al. 1992 ; Functional characteristics of sperm obtained by electroejaculation see comments ; . J. Urol., 147, 6972. Denil, J., Kupker, W., Al-Hasani, S. et al. 1996 ; Successful combination of transrectal electroejaculation and intracytoplasmic sperm injection in the treatment of anejaculation. Hum. Reprod., 11, 12471249. Donohue, J.P., Thornhill, J.A., Foster, R.S. et al. 1993 ; Retroperitoneal lymphadenectomy for clinical stage A testis cancer 1965 to 1989 ; : modifications of technique and impact on ejaculation. J. Urol., 149, 237243. Drawz, B. and Drawz, G. 1992 ; Erfahrungen bei der Anwendung eines kombinierten Prozedere zur Behandlung organisch bedingter Ejakulationsstrungen. Fertilitt, 8, 114118. Dubin, L. and Amelar, R.D. 1972 ; Sexual causes of male infertility. Fertil. Steril., 23, 579582. Elliot, S., Szasz, G. and Zouves, C. 1991 ; The combined use of vibrostimulation and in vitro fertilization: successful pregnancy outcome from a retrograde specimen obtained from a spinal cord-injured male. J. In Vitro Fertil. Embryo Transfer, 8, 348352. Eppel, S.M. and Berzin, M. 1984 ; Pregnancy following treatment of retrograde ejaculation with clomipramine hydrochloride. A report of 3 cases. S. Afr. Med. J., 66, 889891. Fiedler, K., Lochner-Ernst, D., Krusmann, G. et al. 1993 ; Two pregnancies after in-vitro fertilization with spermatozoa from alloplastic spermatocoeles. Hum. Reprod., 8, 422424. Fischer, I. and Coats, E.C. 1954 ; Sterility due to retrograde ejaculation of semen. Obstet. Gynecol., 4, 352354. Fossa, S.D., Ous, S., Abyholm, T. and Loeb, M. 1985 ; Post-treatment fertility in patients with testicular cancer. I. Influence of retroperitoneal lymph node dissection on ejaculatory potency. Br. J. Urol., 57, 204209. Francois, N., Maury, M., Jouannet, D. et al. 1978 ; Electro-ejaculation of a complete paraplegic followed by pregnancy. Paraplegia, 16, 248251.
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3 g g twice daily to the affected skin of the right or left arm according to their birth year. Topical dithranol supplemented with salicylic acid 2% ; was applied to the rest of the body every evening for 12 hours. Depending on skin phototypes, narrowband UVB starting from 0.2 to 0.4 J cm 2 was delivered five times a week and its dosage was gradually increased to a maximum of 2.5 J cm2. Patients were assessed using a modified PASI score and a questionnaire on quality of life. Both combinations were found to be equally effective and complete clearance was achieved after a mean of four weeks. Statistical analysis showed no significant differences in terms of the reduction of the modified PASI score at any time. Some patients preferred calcitriol as it caused less irritation. The authors suggested that combination therapy of narrow-band UVB with calcitriol was as effective as the combination with dithranol in treating psoriasis. However, the small number of patients is a major drawback in this study. Other defects include the lack of blinding and asymmetrical application of the two medications on the subjects.
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Diabetes Care News is published quarterly by Sampling Canada for inclusion in the Canadian Diabetes Care Guide Professional Pack. Address all correspondence to: Alan Donaldson President & Publisher Canadian Diabetes Care Guide 33 Wheeler Avenue Toronto, Ontario M4L 3V3 Tel: 416.690.4871 Fax: 416.690.3553 alan diabetescareguide diabetescareguide.
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4. Greenwald SE, Berry CL, Ramsey RE. The static mechanical properties and chemical composition of the rat aorta in spontaneously occurring and experimentally induced hypertension: the effect of an anti-hypertensive drug. Br J Exp Pathol. 1985; 66: 633-642. Berry CL, Greenwald SE. Effect of hypertension on the static mechanical properties and chemical composition of the rat aorta. Cardiovasc Res. 1976; 10: 437-451. Levy BI, Benessiano J, Poitevin P, Lukin L, Safar ME. Systemic arterial compliance in normotensive and hypertensive rats. J Cardiovasc Pharmacol. 1985; 7: S28-S32. 7. Owens GK, Schwartz SM. Alterations in vascular smooth muscle mass in the spontaneously hypertensive rat. Circ Res. 1982; 51: 280-289. Struyker Boudier HAJ, De Mey JG, Smits JFM, Nievelstein HMNW. Hemodynamic actions of calcium entry blockers. Prog Basic Clin Pharmacol. 1989; 2: 21-66. Safar ME, Simon AC, Levenson JA, Cazor JL. Hemodynamic effects of diltiazem in hypertension. Circ Res. 1983; 52 suppl I ; : I69-1-73. 10. Yano M, Kumada T, Matsuzaki M, et al. Effect of diltiazem on aortic pressure-diameter relationship in dogs. J Physiol. 1989; 256: H1580-H1587. 11. Levy BI, El Fertak L, Piedeloup C, Barouki F, Safar ME. Role of endothelium in the mechanical response of the carotid arterial wall to calcium blockade in SHR and WKY rat. J Hypertens. 1993; 11: 57-63. Nyborg NCB, Mulvany MJ. Lack of effect of antihypertensive treatment with felodipine on cardiovascular structure of young spontaneously hypertensive rats. Cardiovasc Res. 1985; 19: 528-536. Aalkjaer C, Eisjaer H, Mulvany MJ. Structure and function of isolated subcutaneous resistance vessels from essential hypertensive patients on antihypertensive treatment. J Hypertens. 1988; 7: 305-310. Lundin SA, Hallback-Nordlander MIL. Regression of structural cardiovascular changes by antihypertensive therapy in spontaneously hypertensive rats. J Hypertens. 1984; 2: 11-18. Pham-Hun-Trung MT, Corvol P. A direct determination of aldosterone. Steroids. 1974; 24: 587-598. Menard J, Catt KJ. Measurement of renin activity, concentration and substrate in rat plasma by radioimmunoassay of angiotensin I. Endocrinology. 1972; 90: 422-430. Benessiano J, Levy BI, Michel JB. Instaneous aortic blood flow measurements with range gated Doppler flowmeter in anesthetized rat. J Pharmacol Methods. 1985; 14: 99 -110. 18. Levy BI, Benessiano J, Poitevin P, Safar ME. Endotheliumdependent mechanical properties of the carotid artery in WKY and SHR: role of angiotensin-converting enzyme inhibition. Circ Res. 1990; 66: 321-328. Huijberts MSP, Wolffenbuttel BHR, Struyker Boudier HAJ, Crinjs FRL, Nieuwenhuijzen Kruseman AC, Poitevin P, Levy BI. Aminoguanidine treatment increases elasticity and decreases fluid filtration of large arteries from diabetic rats. J Clin Invest. 1993; 92: 1407-1411. Tedgui A, Lever MJ. Filtration through damaged and undamaged rabbit thoracic aorta. J Physiol. 1984; 247: H784-H791. 21. Serra J. Image Analysis and Mathematical Morphology. London: Academic Press Inc; 1982: 31-52. 22. Salzmann JL, Azizi M, Michel JB, Camilleri JP. Aortic media structural parameters study using mathematical morphology processor analysis. Acta Stereologica. 1987; 6: 437-441. Zar JH. Biostatistical Analysis. Englewood, NJ: Prentice-Hall Inc; 1984. 24. Hwa JJ, Bevan JA. A nimodipine-resistant Ca21 pathway is involved in myogenic tone in resistance artery. J Physiol. 1986; 250: H87-H95. 25. Nievelstein HMNW, van Essen H, Tijssen CM, Smits JFM, Struyker-Boudier HAJ. Systemic and regional actions of calcium entry blockers in conscious spontaneously hypertensive rats. Eur J Pharmacol. 1985; 113: 187-198. Cody RJ. The hemodynamics of calcium channel antagonists in hypertension: vascular and myocardial responses. Circulation. 1987; 75: 1175-1179 and mechlorethamine.
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Twenty-four children showed I54V and 20 of these showed V82A F. When we analysed the virological impact of the I54V and V82A F mutations combined, we have shown that children with I54V and V82A F had a high prevalence of other lopinavir mutations L10I, K20R, L24I, V32I, L33F, M46L, L63P, A71V T, G73S, V82A F, I84V and L90M ; Figure 1a ; . Children with both mutations had a median of 7 lopinavir mutations range: 4; 10 ; in contrast to a median of 4 range: 0; 8 ; in children without the two mutations P 0.001 ; . Moreover, children with I54V and V82A F mutations also showed a high prevalence of RT mutations Figure 1b and c ; . Thus, they had a median of 5 NRTI mutations range: 2; 8 ; in contrast to a median of 4 range: 0; 9 ; in children without I54V and V82A F P 0.532 ; . Also, HIV-infected children with I54V and V82A F showed a median of 2 range: 0; 2 ; in contrast to a median of 0 range: 0; 3 ; NNRTI mutations in children without the two mutations P 0.018 ; . I54V and V82A F were associated with virological failure; so, the median time to achieve VL 400 copies mL was higher with I54V and V82A F P 0.005 ; Figure 1c ; . In addition, children with I54V and V82A F had VL higher than children without the two mutations P 0.05 ; for the first 12 months of follow-up Figure 1d ; . Children with I54V and V82A F had the lowest probability of achieving VL 400 copies mL Table 3 ; . I54V and V82A F PI had a negative association with achieving undetectable VL and with having virological suppression VL 400 copies mL ; for at least 6 months and meclizine.
At present, there are two compounds based on THC that are marketed as prescription drugs. Dronabinol Marinol ; is synthetic THC, structurally identical to the psychoactive THC found in marijuana. It has been approved for use in the United States since 1986, and is also commercially available in Canada. Nabilone Cesamet ; is an analogue of THC. It is available by prescription in Canada and the United Kingdom, however the United States has not approved this drug for prescription use. Both drugs are available in pill form. Other forms of synthetic THC exist, such as levonantrodol, a THC analogue, and HU-210, which is an analogue much more potent than the THC found in marijuana.8 These drugs are not commercially available and have not been approved for prescription use
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40. Gonzalez, FJ. and Korzekwa, K.R. 1995 ; Cytochromes P450 expression systems. Annu. Rev. Pharmacol Toxicol, 35, 369-390. 41.Liu, S.Y. and Gonzalez, FJ. 1995 ; Role of the liver-enriched transcription factor HNF-la in expression of the CYP2E1 gene. DNA Cell Biol, 14, 285-293. 42.ChenJ ; ., Lepar.G. and Kemper3. 1994 ; Transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4. J. Biol Chem., 269, 5420-5427. 43. ShawJ'.M., Weiss, M.C. and Adesnik, M. 1994 ; Hepatocyte nuclear factor 3 is a major determinant of CYP2C6 promoter activity in hepatoma cells. Mol Pharmacol, 46, 79-87. Received on July 25, 1995; revised on January 19, 1996; accepted on January 23, 1996 and mefloquine.
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