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Intrinsic CL was scaled-up to predictions of CL as described above. Both the well-stirred and parallel tube models of hepatic CL equations 13, 14, 16 and 17 ; were applied. Methods C2a and C2c disregarded the impact of protein binding equations 16 and 17, respectively ; , whereas methods C2b and C2d included this parameter in the prediction equations 13 and 14, respectively ; . As with the in vitro t1 2 methods, a standard value of 45 mg of microsomal protein g of liver weight was used in the scale-up of in vitro intrinsic CL data, and values of 20 g liver kg of body weight and 20 ml min kg hepatic blood flow were also used. Allometric scaling with protein binding and MLP correction factor method C3a ; . In allometric scaling of CL, the physiological parameter used in the scaling was total body weight. In the case of this method, corrections for interspecies differences in both plasma protein binding and MLP Boxenbaum, 1982 ; were applied. For plasma protein binding, free CL is defined as.

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It is concluded that clorazepate may be a useful treatment for some cases of chronic psychosis and psychotic misidentification and clove. HST after the K fragment impact, and the frequencydependent enhancements of decimetric synchrotron emissions observed after the impacts. Professor Paul Cloutier and his students continued their analysis of 14 years of Pioneer Venus Orbiter data. Accomplishments to date include extensive study of the dayside ionosphere of Venus covering a variety of topics, such as 1 wave-particle mechanisms at the ionopause, including missing pressure in the Venus ionosphere, and a model of superthermal ion behavior; 2 structure and dynamics of the Venus ionopause and ionosphere, including Venus ionopause formation, and magnetic signatures and structure in the dayside Venus ionosphere; and 3 flows and fields in the Venus ionosphere, including refinement of the flow field models of the ionosphere with comparative applications for other solar system bodies. In addition, progress continues to be made in understanding the dynamics of the nightside ionosphere of Venus, such as the structure, instabilities, and electric field noise in Venus's ion troughs. Recent work includes the discovery of a magnetic field rotation at the dayside Venus ionopause which correlates with the boundary between post-shock solar wind flow and Venus thermal ions. From these observations a new configuration for the dayside magnetic field draping has been derived. In addition, a new current system to account for this changing field orientation is being explored. These new features of the dayside have instigated a reexamination of the mechanics driving the solar wind interaction at Venus. While the data currently available is specific to Venus, there is a great opportunity for comparative atmospheric studies. Assuming Mars also represents a non-magnetic obstacle to the flow, as past experimental observations indicate, the field diagnostics established at Venus make it possible to probe the structure of the Martian ionosphere using magnetometer data in the absence of ion mass spectrometer data. This discovery has led to diagnostic tools for interpretation of the Mars Global Surveyor magnetometer experiment data, for which Cloutier serves as a Co-Investigator. Early results from the MGS project indicate a crustal remnant field of surprising variation across the surface of the planet. Already data have shown what appear to be a range of solar wind interactions taking place including one similar to Venus. The next year will be very busy analyzing the vast amounts of data from MGS. Currently Cloutier and graduate student Dana Crider are working on mapping the electric potential across the dayside of Venus. Cloutier and graduate student Pete Walker have recently finished a current model for the nightside Venus ionosphere and are working on matching it with the dayside ionosphere using the thesis results of Research Scientist Colin Law. Law is now working on Mars Global Surveyor data while extending his Venus research. 4.2 Galactic Astronomy 4.2.1 Young Stellar Objects Assistant Professor Patrick Hartigan continued his research into the formation of shock waves within stellar jets. As part of a collaboration led by B. Reipurth ESO , Harti.

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