1. Jemal A, Murray T, Samuels A et al. Cancer statistics, 2003. CA Cancer J Clin 2003; 53: 526. Singletary SE, Allred C, Ashley P et al. Revision of the American Joint Committee on Cancer Staging System for Breast Cancer. J Clin Oncol 2002; 20: 36283636. Scholl SM, Fourquet A, Asselain B et al. Neoadjuvant versus adjuvant chemotherapy in premenopausal patients with tumors considered too large for breast conserving surgery: Preliminary results of a randomized trial: S6. Eur J Cancer 1994; 5: 645 Fisher B, Brown A, Mamounas E et al. Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: Findings from National Surgical Adjuvant Breast and Bowel Project B-18. J Clin Oncol 1997; 15: 2483 Kedar RP, Cosgrove DS, Smith IE et al. Breast carcinoma: measurement of tumor response to primary medical therapy with color flow Doppler imaging. Radiology 1994; 190: 825 Abraham DC, Jones RC, Jones SE et al. Evaluation of neoadjuvant chemotherapeutic response of locally advanced breast cancer by magnetic resonance imaging. Cancer 1996; 78: 91100. Gilles R, Guinebretiere JM, Toussaint C et al. Locally advanced breast cancer: contrast-enhanced subtraction MR imaging of response to preoperative chemotherapy. Radiology 1994; 191: 633638. Machiavelli MR, Romero AO, Perez JE et al. Prognostic significance of pathological response of primary tumor and metastatic axillary lymph nodes after neoadjuvant chemotherapy for locally advanced breast carcinoma. Cancer J Sci 1998; 4: 125131. Honkoop AH, van Diest PJ, de Jong JS et al. Prognostic role of clinical, pathological and biological characteristics in patients with locally advanced breast cancer. Br J Cancer 1998; 77: 621626.
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Ously ; was dermatomed and mounted in flow-through diffusion cells. Dermatomed human cadaver skin was also used. Radiolabeled bifenthrin B ; , deltamethrin D ; or cis-permethrin P ; rat-10, 30 and 100 nmole; human-10 and 100 nmole ; was applied in acetone to the skin. Fractions of receptor fluid were collected every 4 h. At the skins were washed with a soap: water mixture to remove unabsorbed chemical. The skin was then solubilized. Two additional experiments with rat skin were done after the wash. These were tape-stripping the skin and collection of receptor fluid for an additional 24 h. Receptor fluid, tape strips, solubilized skin and skin washes were analyzed for radioactivity. In rat, the 24 h cumulative % of the applied dose in the receptor fluid ranged from 1-2% for B, 1-4% for D and 2-5% for P. In the wash, the % dose was 59-69% for B, 26-28% for D and 33-41% for P. The % dose in skin was 33-43% for B, 26-28% for D and 33-41% for P. Tape stripping washed skin at 24 h removed 5% of the dose for B and D and 1% for P. The % dose in the receptor fluid collected from 24-48 h was 1% for B, 2% for D and 3% for P. For human skin, the 24 h cumulative % dose in receptor fluid was 1% for B, 1-2% for D and 2% for P. In the wash, the % dose was 75-83% for B, 78-79% for D and 71-72% for P. The % dose in skin was 14-21% for B, 14-15% for D and 22-24% for P. A low percentage of the dose of B, D and P completely penetrated rat and human skin. A higher percentage of the dose of these compounds was in the skin of rat than in human skin. Rat skin is more permeable than human skin to B, D and P. A considerable amount of B, D or remains in rat skin after washing and may completely diffuse through it. Consideration of the skin type used and fractions analyzed are important when using in vitro dermal absorption data for risk assessment. This abstract may not represent US EPA policy.
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Several cytokines, especially granulocyte macrophage colony-stimulating factor GM-CSF ; and tumor necrosis factor ot TNF-o0, have been identified that foster the development of dendritic cells from blood and bone marrow precursors in suspension cultures. These precursors are reported to be infrequent or to yield small numbers of dendritic cells in colony-forming assays. Here we readily identify dendritic cell colony-forming units CFU-DC ; that give rise to pure dendritic cell colonies. Human CD34 + bone marrow progenitors were expanded in semisolid cultures with serum-replete medium containing c-kit-hgand, GM-CSF, and TNF-0t. The addition of TNF-ct to GM-CSF did not alter the number of typical GM colonies but did generate pure dendritic cell colonies that accounted for N40% of the total colony growth. When the two distinct types of colonies were plucked from methylcellulose and tested for T cellstimulatory activity in the mixed leukocyte reaction, the potency of colony-derived dendritic cells exceeded that of C F progeny from the same cultures by at least 1.5-2 logs. Immunophenotyping and cytochemical staining of the CFU-DC-derived progeny was also characteristic of dendritic cells. Other myeloid cells were not identified in these colonies. The addition of c-kit-ligand to G M - C and TNF-ot--supplemented suspensions of CD34 bone marrow cells expanded CFU-DCs almost 100-fold by 14 d. We conclude that normal human CD34 + bone marrow cells include substantial numbers ofclonogenic progenitors, distinct from CFU-GMs, that can give rise to pure dendritic cell colonies. These CFU-DCs can be expanded for several weeks by in vitro culture with c-kit-ligand, and their differentiation requires exogenous TNF-0t in addition to GM-CSF. We speculate that this dendritic cell-committed pathway may in the steady state contribute cells to the epidermis and afferent lymph, where dendritic cells are the principal myeloid cell type, and may increase the numbers of these specialized antigen-presenting cells during T cell-mediated immune responses and methyldopa.
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Product Composition Figure 4 shows the sectoral composition of Trinidad and Tobago's exports to the world. Despite recent attempts at export diversification, fuels oil and gas ; account for around 55 percent of total exports period average 1998-2001 ; , 6 and there has been no notable decline in that share over the last decade. Annual variations in the share are to a large extent explained by trends in international fuel prices. Trinidad and Tobago has witnessed large fluctuations in such prices over the past two decades, with price hikes generating increased investment, consumption and economic growth, and subsequent price falls leading to output contraction, declining per capita income, high unemployment, rising current account deficits and loss of foreign exchange reserves. An additional challenge in this sector, beyond high price and income volatility, is the fact that the country's oil and natural gas reserves are finite. This challenge is more acute with respect to the country's oil reserves than for natural gas: according to some estimates, crude oil reserves are expected to last only another decade or so unless new reserves are found. In contrast, proven natural gas reserves are abundant and, with current levels of production, should last at least another 50 years.7 Manufactured goods raised their share in total exports from an average 29 percent in 1990-1993 to 38 percent in 1998-2001. Export growth in this sector has been much faster than growth in the country's total exports. A more careful product analysis nevertheless reveals that much of this growth is due to the increase in exports of one product only, namely SITC 79382 light vessels, fire floats, dredgers ; , exported mainly to Mexico and the United States, and mainly in the final year for which we have detailed product data 2001 ; . Another feature of Trinidad and Tobago's manufactured exports is that natural gas-based products ammonia, methyl alcohol and urea ; account for a large share of such exports, and that diversification in this sector remains quite limited, with just six products accounting for over 70 percent of the value of total manufactured exports in 2001
| Glioma LGG ; . Meeting: 2006 ASCO Annual Meeting Abstract No: 1500 First Author: E. G. Shaw Category: Central Nervous System Tumors - CNS Tumors 2. Study design considerations for phase II trials of anaplastic gliomas and its impact on phase III survival studies. Meeting: 2006 ASCO Annual Meeting Abstract No: 1501 First Author: V. A. Levin Category: Central Nervous System Tumors - CNS Tumors 3. Significance of necrosis in grading of anaplastic oligodendroglial tumors: A clinicopathological and genetic study of 916 high-grade gliomas. Meeting: 2006 ASCO Annual Meeting Abstract No: 1502 First Author: C. R. Miller Category: Central Nervous System Tumors - CNS Tumors More and methysergide.
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N C not calculable * This is for the nine months to 31 Dec 31 #BRW Dec 12-18, 2002 Comparing the companies' revenue and after tax profit, Philip Morris is ranked higher -- 130 compared to 208 for BATA out of the top 1000. This higher placing for Philip Morris also translates into rankings for the companies in the Beverages and tobacco sector of the Australian economy where Philip Morris is at 9 compared to BATA at 14. This higher level of profit for Philip Morris from a considerably lower revenue base is probably a reflection of a much more efficient cigarette manufacturing and distribution process. Profit figures for BATA were million in the 12 months prior and company representatives report the profit decline to be associated with ongoing restructuring costs associated with the merger of WD &HO Wills and Rothmans25. Imperial Tobacco doesn't feature in the top 1000 companies for 2001-02 therefore its revenue must be less than the 0.3 million cut off. Table 4: Shareholder Funds and Total Assets Company balance date ; Amount $M ; BAT Australasia 12 01 ; Philip Morris 12 01 ; 1, 614.7 Shareholders Funds Change % ; N C 99 Rank Amount $m ; 3410.2 Change % ; N C 120 Rank Total Assets.
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Data is that these patients are not experiencing very much pain, and that the other measures in the protocol were working effectively. Side Effects Nausea, and, to a lesser extent, vomiting were the most frequent side effects. These two problems were most prevalent immediately after surgery and decreased progressively afterwards. Almost 40% of patients experienced some nausea when specifically asked about it in the recovery room. Twenty-five percent 25% ; vomited in the recovery room and 8% vomited more than once. On days 2 through 5, vomiting decreased dramatically, and the nausea also decreased. However, nausea was still 20% on day 3 and 10% on day 5 Fig. 5 ; . Other gastrointestinal side effects such as indigestion, diarrhea, and abdominal pain were infrequent, although it is interesting that all of these tended to increase slightly from day 1 to day 4. Headache was a surprisingly common side effect, and remained approximately 20% to 25% from day 2 through day 5 Fig. 6 ; . Admissions Two patients required admission to the hospital after outpatient ACLR at our facility before this study, but no.
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Pharmacodynamic PD ; research explores complex antibiotic, bacterial and host interactions with the aim of improving the treatment of infectious diseases. Unlike traditional microbiological tests i.e. MICs, MBCs ; , in vitro pharmacodynamic models IPDMs ; characterize important relationships between antibiotic concentrations, bacterial susceptibilities.
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Materials Tablets Sulfanilamide purum, 98.0%; FLUKA, Buchs SG, Switzerland and Riedel-de Han, Seelze, Germany ; , microcryse talline cellulose Avicel PH-200 NF, FMC, Newark, DE ; , lactose anhydrous for direct compression Sheffield Brand Lactose NF, Quest International, Chicago, IL ; , and magnesium stearate Witco Corp, Houston, TX ; were sieved through a #30 US standard sieve to make the directly compressible formulation for the tablets. Coating Hydroxypropyl methylcellulose [HPMC] Methocel E3 grade, Dow Chemical Co, Midland, MI ; and polyethylene glycol 6000 USP EP, Dow Chemical Co ; were used as received. Tablet Compression All of the tablet ingredients were blended in a Tote bin blender. Tablets containing 30% w w microcrystalline cellulose, 50% w w lactose anhydrous, 20% w w sulfanilamide, and 0.2% w w of total weight for magnesium stearate were compressed with a 7 16-in standard round concave punches to a target weight of 480 mg on a Stokes 16-station B2 tablet press FJ Stokes Machine Co, Philadelphia, PA ; . Coating Solution An aqueous-based coating solution was prepared, consisting of 10% w w hydroxypropyl methylcellulose and 1% w w polyethylene glycol. The polyethylene glycol was added to 7 L 60C distilled water. After the polyethylene glycol was dissolved, the hydroxypropyl methylcellulose was slowly added, and the solution was mixed for 20 minutes to fully disperse the polymer. The solution was removed from the heat and allowed to sit for at least 12 hours before use to hydrate the polymer. Equipment Film coating experiments were performed in a 24-in diameter Accela-Cota pan coater using a single 2-phase coating and mifepristone.
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M126 Evaluation of the FAMACHA system in lactating goats. M. Rovai * 1, T. A. Gipson1, and L. J. Dawson1, 2, 1E Kika ; de la Garza American Institute for Goat Research, Langston University, Langston, OK, USA, 2Oklahoma State University. College of Veterinary Medicine, Stillwater. The FAMACHA system has been adopted as a useful tool in meat goats for identifying clinical anemia associated with parasitism. However, the applicability of this method in dairy goats remains uncertain. The relation between FAMACHA system FAM; scale based on the ocular conjunctiva color; 12 healthy, 3 border line, and 45 pale ; , fecal egg counts FEC ; and blood packed cell volume PCV ; were studied in 24 Alpine dairy goats measured every 2 wk throughout 7 month of lactation. All does were drenched with an anthelmintic at kidding. Samples for FEC were determined using modied McMaster method and classied as: low 750 ; and high 750 ; eggs per gram feces. For PCV, measured by the microhaematocrit method, values of 19, 2025, and 25 were considered anemic, border line, and healthy, respectively. A false positive result was dened as animals with FAM 45 but not anemic and a false negative as animals with FAM 12 but anemic. The FEC values, log transformed, were affected by FAM P 0.05 ; where scores 4 and 5 showed low FEC 2.42, 2.49, and 2.23 for scores 12, 3, and 45, respectively ; . Moreover, high FEC had a tendency P 0.07 ; for low PCV values 2.52, 2.37, and 2.24 for anemic, border line, and healthy, respectively ; . For low FEC, 37% of animals were classied as FAM 45, 48% as border line, and only 15% FAM 12. The relation between FEC and PCV also presented a negative tendency P 0.07 ; which reafrms the presence of high FEC with low PCV and, consequently, anemia. About 8.5% of goats would have been correctly treated with eye scores of 45 and low PCV values. However, 21% of the goats were false positive and would have 43.
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