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Writers' Association. Before getting his Master's in English and embarking on a teaching career, Brown was a professional ? ; musician and also a free-lance writer for several music publications, including Crawdaddy, and Country Music Magazine. In his spare time, Brown enjoys playing music with friends, writing poetry, painting, and bicycling. He lives in semi-rural Wilson County with wife Billye, son Casey, and "too freaking many cats." Andrew Burson a senior at Western Ke n t University, is pursuing a degree in English, enjoying sunny days and groggy nights. He leads a simple life and gets giddy when he sees animals. He wants to own a dog, but his landlord says "No!" He graduates May, 2006 and will move "the hell out of Kentucky" shortly there after. Marion Davidson is the author of Closeness of Ice, a chapbook of poems released by Finishing Line Press in November, 2004. Recent poems have appeared in Sunday Oregonian, Hubbub, Ellipsis, Firefly, RATTLE, Troubadour, Cascade Reader, Signpost and several anthologies. A retired attorney, she lives in Bend, Oregon. Beverly Head is Chair of the Humanities and Fine Arts Division at Atlanta Metropolitan College. Her book of poetry, Walking North, was published by Michigan State Press as part of the Lotus Poetry Series. Jennifer Highland practices medicine in central New Hampshire. Her poetry has appeared in Potpourri, Confrontation, and The Northern New England Review. Elizabeth Howard Elizabeth Howard lives in Crossville, Tennessee. She has an M.A. in English from Vanderbilt University. Her work has appeared in Xavier Review, Cold Mountain Review, Comstock Review, Wind, Poem, and other journals. She has two books of poetry Anemones 1998 ; and Gleaners 2005 ; . Jeanne Irelan is a retired Volunteer State Community College English teacher and former Director of the Writing Center, having been a long-time.
We thank Dr. Fleet for his interest in our study 1 ; and appreciate his comments. We agree with Dr. Fleet as to the necessity of further evidence to establish the clinical significance of noncardiac analysis in cardiac multidetector computed tomography MDCT ; . Our study lacks long-term clinical follow-up to discuss clinical outcomes. In addition, we did not discuss cost because the actual cost of additional follow-up, including surgery, biopsy, and imaging, varies among countries and institutions. As clinical results and costs could be different depending on how referring physicians.
Table 4-1 - Listing of chemotherapy agents by renal involvement * Renal toxic Preferred term Preferred term Adriamycin + Cyclophosphamide Methotrexate Adriamycin + Vincristine + MTX Methotrexate sodium Aldesleukin Mitomycin BCG Vaccine Oxaliplatin Carboplatin Paclitaxel Cisplatin Raltitrexed Cyclophosphamide Streptozocin Cyclophosphamide + 5-FU + Methotrexate Strontium-89 Cyclophosphamide + 5-FU + Prednisolone Taxol + Carboplatin Cyclophosphamide + Doxorubicin + 5-FU Tegafur Cyclophosphamide + Epirubicin Tegafur Uracil Dacarbazine Teniposide Etanercept Thalidomide Gallium Nitrate Thiotepa Gemcitabine Topotecan Hydrochloride Gemcitabine Hydrochloride Trastuzumab Hydroxycarbamide Carboplatin + Etoposide Ifosfamide CMF + Dexamethasone Interferon CMF + Tamoxifen Interferon Alfa FAC + Tamoxifen Citrate Interferon Beta Topotecan Interferon Gamma EVCMF Interferon Nos Epirubicine + Vincri. + Cycloph. + MTX + 5FU ; Interleukin-2 M - VAC.
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A study of the Finnish National Public Health Institute at Kuopio evaluated the association between serum mold-specific IgG levels in primary school children with asthma, wheezing, or cough symptoms and exposure to indoor mold in 2 schools with and without mold damage, and found that IgG analysis cannot be readily suggested as a routine method for the evaluation of these exposures [36]. Scientists of the same institution tested the hypothesis that maternal sex hormone concentrations during early pregnancy are associated with the risk of onset of asthma in the child but did not find a significant relationship [72]. Their colleagues at the Finnish University of Oulu evaluated the controversal role of early respiratory syncytial virus infection in allergic sensitization and found that an early RSV infection results in a reduction of skin prick test positivity but not in a reduced occurence of atopic disease [40]. Researchers of the Centre for Public Health at Berlin assessed the combined effects of chronic exposure to traffic-related air pollution and noise upon the risk of skin and respiratory diseases in children [37]. Their results suggest a significant risk for asthma with increasing traffic load. Scientists of the German GSF found no convincing association between maternal oral contraceptive use and atopic diseases in children [26]. The German MAS90 group analyzed prevalences of allergic sensitization and atopic disease in relation to vaccination coverage and found that children with a higher vaccination coverage seemed to be transiently better protected against development of atopy in the first year [27]. The research team of Erika von Mutius at the Ludwig Maximilians University Munich evaluated the relationship between traffic exposure and inception of atopy in large random samples of school children [54]. They found that high vehicle traffic was associated with asthma, cough and wheeze, and in children additionally exposed to environmental tobacco smoke, with allergic sensitisation. In another study, they addressed the interdependencies of exposue to furred pets in infancy and the prevalence of asthma, and found that allowing cats to be in the child's bedrom from the first year of life onwards may be an indicator of intensive exposure to cats and appears to prevent the development of childhood asthma [56]. Researchers of the UFZ - Centre for Environmental Research at Leipzig presented two publications: One was about the influence of redecoration of the appartment on airway symptoms in infants during the first two years of life, and it suggested a significant assocation between redecoration of the apartment and obstructive bronchitis in the infant [22]. Another study assessed the influence of spatial and temporal variations in the urban air pollution profile on asthmatic disease in young children [25]. Depending on the level of traffic high or low ; , children residing in areas with a dominant coal-heating emission profile had more frequently a diagnosis of asthma. The Insitute for Environmental Research at Duesseldorf performed a study about the impact of environmental tobacco smoke on atopic eczema, allergic sensitization and allergic airway diseases in a large sample of school beginners [45].
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Shall it be known when he is unclean. If his flesh run, or if his flesh congeal by the reason of his issue, then he is unclean. Every couch whereon he lieth and every thing whereon he sitteth shall be unclean. He that toucheth his couch, shall wash his clothes and bathe himself with water, and be unclean until the evening. He that sitteth on that whereon he sat, shall wash his clothes and bathe himself with water and be unclean until the evening. And he that toucheth his flesh shall wash his clothes, and bathe himself in water, and be unclean unto the evening. If any such spit upon him that is clean, he must wash his clothes and bathe himself in water and be unclean until evening. And whatsoever saddle that he rideth upon, shall be unclean. And whosoever toucheth anything that was under him, shall be unclean unto the evening. And he that beareth any such things shall wash his clothes, and bathe himself in water and be unclean unto the evening, and whosoever he toucheth if he have not first washed his hands in water ; must wash his clothes, and bathe himself in water, and be unclean unto the evening. And if he touch a vessel of earth, it shall be broken: and all vessels of wood shall be rinsed in the water. When he that hath an issue is cleansed of his issue, let him number seven days after he is clean, and wash his clothes, and bathe his flesh in running water, and then he is clean. And the eighth day let him take two turtle doves or two young pigeons, and come before the Lord unto the door of the tabernacle of witness, and give them unto the Priest. And the Priest shall offer them: the one for a sinoffering, and the other for a burntoffering: and make an atonement for him before the Lord, as concerning his issue. If any mans seed depart from him in his sleep, he shall wash his flesh in water and be unclean until evening. And all the clothes or furs whereon such seed chanceth shall be washed with water and be unclean unto the evening. And if a woman lie with such a one, they shall wash themselves with water and be unclean until evening. When a womans natural course of blood runneth, she shall be put apart seven days: and whosoever toucheth her shall be unclean unto the evening. And all that she lieth or sitteth upon as long as she is put apart shall be unclean. And whosoever toucheth her couch shall wash his clothes and bathe himself with water and be unclean unto the evening. And whosoever toucheth anything that she sat upon, shall wash his clothes and wash himself also in water, and be unclean unto the evening: so that whether he.
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A systematic search was made on the sequence -our. Instances in which the "American" spelling has -or yielded entries in Field 6 when the word in question might reasonably be used as a search word. Behaviour is seldom a sensible search word e.g., asymptotic behaviour would be found by looking for asymptotic ; and so has not usually been respelled. However, behavioural science, nearest neighbour, Prohorov neighbourhood, labour market, tumour growth, coloured noise, etc. have been respelled. On an.
1st dam SHAM BASTY, by Sham. Winner at 2, , 933. Dam of 3 foals of racing age, including a 2-year-old of 2005, two to race, one winner-Baileys Jet g. by Mister Baileys-GB ; . Winner at 3, , 654. 2nd dam * BASTY, by Bobby. 6 wins, 2 to 4 in Argentina, Premio Club Hipico de Santiago de Chile, Premio Bonzo, Premio Tespia, Premio Venezuela, Premio Jockey Club de San Pablo, 2nd Premio Helda, Premio Black Beauty, Premio Arturo A. Bullrich, Premio Paulina, Premio Clemente Benavides, 3rd Premio Monserga, Premio Chile, Premio Nogoya, Premio Caballerizas Argentinas, Premio Jockey Club de Peru, Premio Trisca, Premio Cote d'Or; 11 wins, 5 to 7, , 285 in N.A. Dam of 5 other foals to race, all winners-Bold Playmate c. by Bold Play ; . 2 wins, 3rd Louisiana Futurity Males-R. True Basty. Winner at 2, , 313. Chadra. Winner at 3, , 826. Dam of 7 winners-Chadra North f. by Far North ; . 8 wins, 2 to 4, , 988, 2nd Lorelei S. LAD, , 000 ; , 3rd Red Camelia H. [R] FG, , 478 ; . Dam of Silver Chadra g. by Silver Deputy ; 10 wins, 4, 525, 2nd Jefferson Cup S. []L], CD, , 100, 3rd Lecomte H. [L], FG, , 000. Bold Chadra g. by Bold Play ; . 4 wins, 2 to 4, , 558, 2nd Louisiana Futurity [R] FG, , 511 ; , Minstrel S. LAD, , 116 ; , Stardust S. [R] LAD, , 920 ; . Chad's Play. 5 wins, 2 to 5, , 639. Hell's Fury. 3 wins at 3 and 5, , 754. Beau Basty. 8 wins at 3 and 4, , 008. Producer. Partez Lady. 5 wins, 2 to 6, , 497. Chadra's Prince. 4 wins, 2 to 5, , 011. Nasty Basty. 4 wins, 2 to 5. Pacific Basty. Winner at 2, , 005. Playful Basty. Unraced. Dam of-Basty Bag'n. Winner at 2, , 005. 3rd dam BAYANITA, by Baxar. Unraced. In Argentina. Dam of- * BASTY. Black type winner, see above. Accredited Texas-bred and terfenadine.
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This review is based on round-table discussions supported by an unrestricted educational grant from the Alliance for Better Bone Health Procter and Gamble Pharmaceuticals and Sanofi-Aventis Pharmaceuticals ; . The authors would like to acknowledge the help of Dr Patricia Macnair, who wrote a summary of the discussion at the first meeting. The views and opinions expressed are those of the named authors.
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According to Canadian researchers, in patients with newly diagnosed type 2 diabetes, short-term intensive insulin therapy can lay the foundation for good long-term glycemic control. The findings are based on a study of 16 patients with newly diagnosed diabetes who were treated with intensive insulin therapy for 2 to 3 weeks. All of the subjects had a fasting glucose level of more than 199mgt dL 11 mmol L ; when the study began. With intensive therapy, the fasting glucose level fell from an average of 239mg dL or 13.3 to 133mg dL or 7.0 mmol L, lead author Dr. Edmond A. Ryan and colleagues, from the University of Alberta in Edmonton, note. Moreover, this improvement was still present one year later.
Table 5, significant reductions were observed in the number of patients reporting one or more occurrences of palpitations or dyspnea, and increases were noted in the intervals between symptoms of palpitations, tachycardia, dyspnea, and chest pain. Thus, parallel reductions in PAF and associated symptoms were observed and thalidomide.
1. Sawyers CL. Chronic myeloid leukemia. N Engl J Med. 1999; 340: 1330-1340. McLaughlin J, Chianese E, Witte ON. In vitro transformation of immature hematopoietic cells by the P210 BCR ABL oncogene product of the Philadelphia chromosome. Proc Natl Acad Sci U S A. 1987; 84: 6558-6562. McGahon A, Bissonnette R, Schmitt M, Cotter KM, Green DR, Cotter TG. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. Blood. 1994; 83: 11791187. Bedi A, Barber JP, Bedi GC, et al. BCR-ABL-mediated inhibition of apoptosis with delay of G2 M transition after DNA damage: a mechanism of resistance to multiple anticancer agents. Blood. 1995; 86: 1148-1158. Amarante-Mendes GP, McGahon AJ, Nishioka WK, Afar DE, Witte ON, Green DR. Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protectionis correlated with up regulation of Bcl-xL. Oncogene. 1998; 16: 1383-1390. Gesbert F, Sellers WR, Signoretti S, Loda M, Griffin JD. BCR ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase AKT pathway. J Biol Chem. 2000; 275: 39223-39230. Kang CD, Yoo SD, Hwang BW, et al. The inhibition of ERK MAPK not the activation of JNK SAPK is primarily required to induce apoptosis in chronic myelogenous leukemic K562 cells. Leuk Res. 2000; 24: 527-534. Sonoyama J, Matsumura I, Ezoe S, et al. Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR ABL in K562 cells. J Biol Chem. 2002; 277: 8076-8082. Rhodes J, York RD, Tara D, Tajinda K, Druker BJ. CrkL functions as a nuclear adaptor and transcriptional activator in Bcr-Abl-expressing cells. Exp Hematol. 2000; 28: 305-310. Druker BJ. Perspectives on the development of a molecularly targeted agent. Cancer Cell. 2002; 1: 31-36. Mow BM, Chandra J, Svingen PA, et al. Effects of the Bcr abl kinase inhibitors STI571 and adaphostin NSC 680410 ; on chronic myelogenous leukemia cells in vitro. Blood. 2002; 99: 664-671. Kawaguchi Y, Jinnai I, Nagai K, et al. Effect of a selective Abl tyrosine kinase inhibitor, STI571, on in vitro growth of BCR-ABL-positive acute lymphoblastic leukemia cells. Leukemia 2001; 15: 590-594. Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001; 344: 1031-1037. Gorre ME, Sawyers CL. Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia. Curr Opin Hematol. 2002; 9: 303-307. Almond JB, Cohen GM. The proteasome: a novel target for cancer chemotherapy. Leukemia. 2002; 16: 433-443. Lin ZP, Boller YC, Amer SM, et al. Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-kappaB activation in drug resistance. Cancer Res. 1998; 58: 3059-3065. Adams J, Palombella VJ, Sausville EA, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999; 59: 2615-2622. An B, Goldfarb RH, Siman R, Dou QP. Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ. 1998; 5: 1062-1075. Cusack JC Jr, Liu R, Houston M, et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res. 2001; 61: 3535-3540. Orlowski RZ, Stinchcombe TE, Mitchell BS, et al. Phase I trial of the proteasome inhibitor PS-341in patients with refractory hematologic malignancies. J Clin Oncol. 2002; 20: 4420-4427. Marks P, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer. 2001 1: 194-202. Rosato RR, Wang Z, Gopalkrishnan RV, Fisher PB, Grant S. Evidence of a functional role for the cyclin-dependent kinase-inhibitor p21WAF1 CIP1 MDA6 in promoting differentiation and preventing mitochondrial dysfunction and apoptosis induced by sodium butyrate in human myelomonocytic leukemia cells U937 ; . Int J Oncol. 2001; 19: 181-191. Ruefli AA, Ausserlechner MJ, Bernhard D, et al. The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid SAHA ; induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc Natl Acad Sci U S A. 2001; 98: 10833-10838. Witt O, Sand K, Pekrun A. Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways. Blood. 2000; 95: 23912396. O'Connor O, Kelly W, Wang ES, et al. Clinical development of the histone deacetylase inhibitor suberoylanalide hyroxamic acid SAHA ; in aggressive non-Hodgkin's lymphoma NHL ; and Hodgkin's disease HD ; [abstract]. Blood. 2001; 98: 611a. Sandor V, Bakke S, Robey RW, et al. Phase I trial of the histone deacetylase inhibitor, depsipeptide FR901228, NSC 630176 ; , in patients with refractory neoplasms. Clin Cancer Res. 2002; 8: 718728. Gore SD, Weng LJ, Figg WD, et al. Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic.
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Dr Simon has received honoraria and research funding from Cordis Johnson & Johnson. Dr Pompili is named as a coinventor on patents filed by Case Western Reserve University that relate to the use of CD133 progenitor cells in cardiovascular disease and is a cofounder of Arteriocyte, Inc, which is developing this technology for clinical applications and thiabendazole.
Consider individual patient profiles, the pathophysiology of ADHF with and without renal dysfunction, as well as what is known and, equally important, unknown about available treatment options. Pathophysiology. The heart failure syndrome cannot be easily reduced to any one cause or pathophysiologic mechanism. It begins with a structural or functional abnormality in the heart's pumping action, often caused by myocardial ischemia or uncontrolled hypertension.6 The functional defect may be systolic or diastolic and typically affects left ventricular function with secondary loss of right ventricular function. Commonly, left ventricular dysfunction will ultimately impair total cardiac func
The plasma concentration of IDA and its principal metabolite idarubicinol IDOL ; was determined during each chemotherapy cycle by highperformance liquid chromatography HPLC ; with fluorescence detection as described in a previous paper [12]. Blood samples were collected in heparinized tubes at baseline and on days 7, 14 and 21 of each cycle immediately before the daily oral dose of IDA Ctrough ; at 09: 00 h and immediately centrifuged. The plasma obtained was stored at 20C until analysis. Part I No. of pts % ; Number of patients Median age range ; years 6570 7175 7680 Median K.P.S. range ; ER status Positive Negative Unknown Number of metastatic sites 01 23 4 Sites of disease Visceral total ; Lung Liver Non-visceral total ; Bone Soft tissue Other 14 74 6784 ; 3 6 3 ; Part II No. of pts % ; 33 75 6581 ; 9 10 13 and thiamin.
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Reactive oxygen species in the cell. The fact that teniposide also up-regulated the mitochondrial expression of manganous superoxide dismutase suggested that free radicals are involved in the pathological changes observed. In this context, therefore, up-regulation of cytochrome c levels in mitochondria may play a protective role during the initial response of cells to drug treatment. Different models have been proposed to explain the mechanism of cytochrome c release from the intermembrane space of mitochondria during apoptosis or necrosis. Swelling and subsequent rupture of the outer mitochondrial membrane have been proposed as a mechanism for the release of cytochrome c into the cytosol 26 ; , events which are usually associated with the mitochondrial PT 27, 28 ; and with a loss of m 28 ; However, cytochrome c appeared in the cytoplasm of teniposide-treated cells with a normal m. Furthermore, using electron microscopy, predominantly hyperdense and condensed mitochondria were observed after teniposide treatment of MDA-MB231 cells data not shown ; , suggesting that the swelling of mitochondria is unlikely to be the primary mechanism of cytochrome c release. Together, these data suggest that mitochondrial depolarization was not required for cytochrome c release, a conclusion that is also consistent with previous results reported by us and by others 17, 29 ; . In conclusion, the present work demonstrated that teniposide and other chemotherapeutic drugs can induce an increase in cytochrome c and other mitochondrial respiratory chain proteins. We have also shown that cytochrome c release from mitochondria to the cytosol is an early event preceding the drop of m and caspase activation. We propose that mitochondrial cytochrome c enrichment may play a critical role in the initial defense response of a cell and precedes the final events leading to extensive cytochrome c release, a drop of m, caspase activation, plasma membrane disruption, and eventually to cell death. ACKNOWLEDGMENTS and thioguanine.
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