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DYSERT, Februarii 22, 1643. The whilk day . Compeired John Davidson commissioner from the parochiners of Portmook who presented his commissioun in wreatt bearing thair full consent to the list proponed to them and that they had pitched upon Mr Georg Ogilbie one of the said list whom they desyred to be thair minister if so be the presentatioun may be purchased to him whereunto the Presbytrie consented. Mr Frederik Carmichell presented ane note of 300 merks resaved be John Meine resaver of the contributioun for Irland ; from him. Kathren Brown compeireing convictt of adulterie : resaved hir first injunctiouns. The brethren supported Agnes Stewart according to thair promeise. Ordeanes the Clerk to insert the covenant into the Presbytrie book with the declaratioun of the Assemblie of Glasgow that it may be subscryvit be all that a r members of the Presbytrie and sall be heirafter. KIRKCALDIE, March 15. The whilk day . The brethren of the Presbytrie without a contrarie voyse ordeanes that these who hes violate the late bygone fast by working sallbe punished as breakers of the Sabbath and this act to have force in all time comeing. Mr John Moncrief all his bygone absences excused, also Mr John Smiths who reported a ticket from John Meine of the receipt of ane hundreth and thretie punds 2 sh resaved be him as collector of the Irish contributioun from the said Mr John Smith for the parochine of Burntiland. Mr John Moncrief is appoynted to preache at Skunie the nixt Sabbath, Mr Josua Meldrom to preache at Portmook. DYSERT, March 22. The whilk day . Harie Forbes produced ane sufficient testimonial from the Presbytrie of Deer whilk was accepted. Compeired John Russell and Marion Dewar in Burntiland she affirming him to be hir bairnes father : he denyes. The mater remitted back to the sessioun of Burntiland to be further tryed. Compeired Mart Alexr in Auchterdirran adultress with Sr Georg Bosuell : resaved hir last injunctiouns. Compeired also Isobell Aiken in Kinglessie trelapse in fornicatioun, ordeaned to satisfie as ane adultress : resaved hir first injunctiouns. KIRKCALDIE, March 29. The whilk day . Compeired my Lord Elcho, Sr Georg Hamilton of Blaikburn, William Rigg of Athernie, who produced a letter from the Lords of his Maties Secret Counsell conservators of peace and commissioners for the cowmon burdens desyreing the advyce and concurrence of the brethren for moveing of thair people that arable to lenn chearefullie upon good suretie for the relief of the distressed armie in Irland, whilk the Presbytrie undertook to doe, and promeises to return thair diligence this day fyftein dayes. Compeired William Rigg of Athernie who desyred the Presbytrie to provyde.
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1. Bouroncle, B. A., Wiseman, B. K., and Doan, C. A. Leukemic reticuloendotheliosis. Blood, 13: 609 630, Cheson, B. D., and Martin, A. Clinical trials in hairy cell leukemia. Current status and future directions [published erratum appears in Ann. Intern. Med., 107: 604, 1987]. Ann. Intern. Med., 106: 871 878, Saven, A., Burian, C., Koziol, J. A., and Piro, L. D. Long-term follow-up of patients with hairy cell leukemia after cladribine treatment. Blood, 92: 1918 1926, Grever, M., Kopecky, K., Foucar, M. K., Head, D., Bennett, J. M., Hutchison, R. E., Corbett, W. E., Cassileth, P. A., Habermann, T., Golomb, H., Rai, K., Eisenhauer, E., Appelbaum, F., and Cheson, B. D. Randomized comparison of pentostatin versus interferon -2a in previously untreated patients with hairy cell leukemia: an intergroup study [see comments]. J. Clin. Oncol., 13: 974 982, Cheson, B. D., Sorensen, J. M., Vena, D. A., Montello, M. J., Barrett, J. A., Damasio, E., Tallman, M., Annino, L., Connors, J., Coiffier, B., and Lauria, F. Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine via the Group C protocol mechanism of the National Cancer Institute: a report of 979 patients. J. Clin. Oncol., 16: 30073015, 1998. Carbone, A., Reato, G., Di Celle, P. F., Lauria, F., and Foa, R. Disease eradication in hairy cell leukemia patients treated with 2chlorodeoxyadenosine. Leukemia Baltimore ; , 8: 2019 2020, Filleul, B., Delannoy, A., Ferrant, A., Zenebergh, A., Van Daele, S., Bosly, A., Doyen, C., Mineur, P., Glorieux, P., Driesschaert, P., Sokal, C., Martiat, P., and Michaux, J. L. A single course of 2-chloro-deoxyadenosine does not eradicate leukemic cells in hairy cell leukemia pa.
Szczesniak , McIntosh BT , Maor Y , Kelly MEM 1 Laboratory for Optic Nerve and Retina Research, 2 Dalhousie University, Halifax, Canada, Department of Medicinal Chemistry and Natural Products, Medical Faculty The Hebrew University of Jerusalem Corresponding Authors: brendan intosh dal , mkelly dal Funding Source: CIHR operating grant MEMK ; , salary awards NSHRF BM ; , Hebrew University YM ; Background: In humans, intraocular pressure IOP ; is determined by the secretion of aqueous humor and outflow resistance via the trabecular and uveoscleral routes. Cannabinoid receptors are present on tissues of both the inflow and outflow pathways and cannabinoid ligands have been shown to decrease IOP in humans. Cannabigerol-dimethyl heptyl CBG-DMH ; is a synthetic non-psychoactive cannabinoid with hypotensive and vassorelaxative properties Maor, et al., 2005 ; . This study investigated the ocular pharmacology of CBG-DMH. Methods: IOP was measured with a tonometer in brown Norway rats at 15 minute intervals for 2 hours. All drugs were administered by intraperitoneal injections. Ratiometric calcium imaging was used to observe the effect of CBG-DMH on human cell lines derived from trabecular meshwork TM ; and ciliary muscle CM ; . Results: 2.5 and 10 mg kg of CBG-DMH reduced IOP in rat eyes 20.90.16 to 19.80.31 mmHg and 20.80.25 to 19.450.15 mmHg, respectively ; mean SEM ; . The IOP-lowering effect of CBG-DMH was significantly reduced by pre-administration of 2.5 mg kg of O-1918, a selective antagonist of nonCB1 CB2 novel endothelial cannabinoid receptor, and SR141716A, a CB1 specific receptor antagonist. In vitro, exposure to 10 M CBG-DMH evoked a gradual increase in [Ca2 + ]i in both TM and CM cells. Conclusions: This study suggests that administration of CBG-DMH effectively decreases IOP in the rat eye. CBG-DMH has activity at CM and TM cells to increase [Ca2 + ]i, which may be associated with, altered contractility and outflow resistance. CBG-DMH has the potential to function as a novel ocular hypotensive cannabinoid devoid of psychotropic activity. Keywords: Intraocular pressure, cannabinoids, cannabigerol-dimethyl heptyl and clofarabine.
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MONTH FIG. 1. The EDSS A ; and SNRS B ; of 48 patients treated with cladribine in a double-blind crossover study. The solid symbols indicate months during which drug was administered. The group of patients denoted by circles was given during 4 mo. The group that received placebo first aJ ; was given 0.7 mg of cladribine 0.7 mg of cladribine per kg of body weight in a 7-day infusion per and two subsequent 7-day infusions of 0.35 mg per kg of body weight second and third kg of body weight as a first infusion first solid square ; solid square ; . The fourth infusion in these patients was placebo, as denoted by the open square. Bars represent 1 SEM. Dashed lines represent changes occurring after the study had been unblinded. EDSS or loss of 10 SNRS points are shown in Fig. 2. Surpristhey had lesions that disappeared. However, the other 12 ingly, time-to-improvement plots data not shown ; also showed a patients were scored as having lesions: 10 because.
Caesarean delivery, smith and colleagues p 375 ; found that women who had not previously given birth vaginally and those whose labour was induced with prostaglandin had a higher risk of uterine rupture when attempting vaginal birth--and if uterine rupture occurred, the risk of the infant dying is lower in obstetric units with higher throughput and clofibrate.
ACIP recommends that young adolescents see a healthcare provider at age 11-12 for a routine preventive visit, at which time appropriate immunizations and other preventive services should be provided For those who have not previously received MCV4, we recommend vaccination before high school entry ~15 years old ; as the most effective strategy towards reducing meningococcal disease incidence in adolescence and young adulthood. College freshman who live in dormitories are at higher risk for meningococcal disease compared to other people of the same age.
There are six national associations which represent the industry and its various sub-sectors. In addition to these six, there are also some minor players in the industry. A brief overview of each of the six is as follows: ROMCONF Members: garment manufacturers, mostly large companies Fees for membership: US$ 50-200 one time membership tax and US$ 10-50 monthly membership dues number of members: 73 registered 56 dues paid to date ; number of staff members: 1 fulltime & 2 collaborators description of products and services offered: o access to information from national and international sources o support with participation to trade promotion events o advocacy and clorazepate
Children play a much more obvious version of this game: "Did not." "Did too." "Did not!" "Did too!" "No, I didn't!" "Yes, you did!" And on, and on. Think of it this way: Whether the kids are privileged to have AD HD or not, it's sometimes a lot more fun to do this, than the alternative. Kids in the back seat of the family car are fond of poking each other for entertainment. It's more fun than just sitting there. And that is code for: it's stimulating. I don't know about you, but the nay-sayers may say, "Nay" all they like; I'd much prefer to take my stimulants from a bottle and have more harmony in my home, thank you.
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2001. Stewart, Dana J. "Middle East Urban Studies: Identity and Meaning." Urban Geography. 22 2001 ; : 175-181 "Middle East Urban Studies II: Growth, Environment and Economic Development." Urban Geography. 23 2002 ; : 388-394. Sweet, Louise E. ed. Peoples and Cultures of the Middle East. Volume 2: Life in the Cities, Towns, and Countryside. New York: The Natural History Press, 1970. Teller, Mathew. A Rough Guide to Jordan. London: Penguin Books Ltd., 2002. Trinquier, Roger. Modern Warfare: A French View of Counterinsurgency. Translated by Daniel Lee. London: Pall Mall Press, 1964. Unknown. "A Living Culture, Middle Eastern Modern Architecture ; ." Architectural Review. March 1998. US Department of the Army. Field Manual FM ; 3-06, Urban Operations. Washington, DC: Government Printing Office, 2003. US Department of the Army. FM 3-06.11, Combined Arms Operations in Urban Terrain. Washington, DC: Government Printing Office, 2002. US Department of the Marine Corps. Marine Corps Intelligence Association MCIA ; -2700-002-03, Urban Generic Intelligence Requirements Handbook UGIRH ; . Quantico, VA: Marine Corps Intelligence Activity, 2003. Utvik, Bjrn Olav and Knut S. Vikr, eds. The Middle East in a Globalized World: Papers from the Fourth Nordic Conference on Middle Eastern Studies, Oslo 1998. "The Shari'a and the Nation State: Who can Codify the Divine Law?" by Knut S. Vikr. London: C. Hurst & Co Ltd., 1998. Wedeman, Ben. "The Genuine Article." The Middle East. 232 March 1994 ; : 41-42 and clove.
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Been used to treat these patients.61 This therapy generally produces a haematological response in the range of 40%, but much lower complete response rates and prolonged myelosuppression often leads to significant organ toxicity, which compromises the ability to proceed to SCT. Investigational therapies include high-dose cladribine [a chlorinated purine analogue]; 62 decitabine [a pyrimidine analogue that inhibits DNA methylation]; 63 and troxacitabine [a novel dioxolane nucleoside analogue].64 The anti-CD33 immunoconjugate gemtuzumab Mylotargs, gemtuzumab ozogmicin for Injection, Wyeth Pharmaceuticals, Philadelphia, PA, USA ; , in combination with other therapies, may have some application in myeloid blastic phase but remains to be evaluated more thoroughly.65 Imatinib is able to induce haematological responses lasting at least 4 weeks in 31% of patients in myeloid blast crisis, including complete haematological responses in 8% of cases.10 Unexpectedly, a major cytogenetic response was achieved in 16% of patients with a complete cytogenetic response in 7%.10 Not surprisingly, achievement of a sustained haematological response appears to be associated with more prolonged survival Figure 7 ; .10 The median survival time of patients with a sustained haematological response was 19 months, compared to 6 months for patients with an unsustained response and only 3 months for patients with no response.10 However, most patients relapse and the current estimate of the 12-month rate of survival is 32%.10 The outcome of SCT is better in blast crisis patients who return to chronic phase prior to transplantation than in patients who undergo transplantation during blast crisis. Thus, the achievement of a haematological response with imatinib in these patients suggests that imatinib may be useful as a bridge to transplantation. Although imatinib produces haematological and even cytogenetic responses in patients in myeloid blast crisis, the rate of relapse and the data on resistance at that stage of disease54 strongly suggest the need to combine imatinib with other therapies.55 In addition to combinations with chemotherapy, farnesyltransferase inhibitors FTI ; represent a new class of agents that target signal transduction pathways responsible for proliferation and survival of diverse malignant cell types. FTIs have shown activity in advanced leukaemia66 and the combination with imatinib may be another rational strategy to increase the.
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From science news, 6 11 94 by kathy fackelmann cladribine definition cladribine, also known by the brand name leustatin, is a chemotherapy medicine used to treat certain types of cancer by destroying and codeine.
5. Romine JS, Sipe JC, Koziol JA, Zyroff J, Beutler E. A doubleblind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis. Proc Assoc Physicians 1999; 111: 3544 Truyen L, van Waesberghe JH, van Walderveen MA, et al. Accumulation of hypointense lesions ``black holes'' ; on T1 spinecho MR correlates with disease progression in multiple sclerosis. Neurology 1996; 47: 14691476 Cohen J. A coefficient of agreement for nominal scales. Educ Psychol Meas 1960; 20: 3745 Fleiss JL. The statistical basis of meta-analysis. Stat Methods Med Res 1993; 2: 121145 Poser CM. Exacerbations, activity, and progression in multiple sclerosis. Arch Neurol 1980; 37: 471474 Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13: 227231 Filippi M, Horsfield MA, Ader HJ, et al. Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis. Ann Neurol 1998; 43: 499506 Tofts PS. Standardisation and optimisation of magnetic resonance techniques for multicentre studies. J Neurol Neurosurg Psychiatry 1998; 64: S37S43 13. Barkhof F, Filippi M, van Waesberghe JH, Campi A, Miller DH, Ader HJ. Interobserver agreement for diagnostic MR criteria in suspected multiple sclerosis. Neuroradiology 1999; 41: 347350 Filippi M, Rovaris M, Capra R, et al. A multi-centre longitudinal study comparing the sensitivity of monthly MRI after standard and triple dose gadolinium-DTPA for monitoring disease activity in multiple sclerosis: implications for phase II clinical trials. Brain 1998; 121: 20112020 O'Riordan J, Gawne Cain M, Coles A, et al. T1 hypointense lesion load in secondary progressive multiple sclerosis: a com.
| Cladribine merck kgaaIf the applicant is taking one of these drugs for the reason stated, he she is not eligible for coverage. This list is a reference guide for prequalifying cases; it is not intended to be an exhaustive, all-inclusive list. Drug name Actimmune Abilify Akineton Aldazine Amantadine Anexsia Antabuse Aranesp Aricept Artane Auranofin Avonex Azathioprine AZT Baclofen Bendopa Benztropine mesylate Betaseron Bromocriptine Carbidopa Chlorpormazine Cladribine Clorazil Clozapine Codeine Cogentin Cognex Combivir Comtan Copaxone Dantrium Dantrolene Darvocet Demerol Deprynel Dilaudid Donepezil Dopar Duragesic Edrophonium Chloride Eldepryl Endocet Epogen Eulexin Exelan Fluphenazine Flutamide Glatiramer acetate Gold compound 8 Alternate name for same drug Interferon gamma 1-b Aripiprazole Biperiden Mellaril, Thioridazine Symmetrel Hydrocodone Disulfiram Darepeotinalfa Donepezil Novohexidyl Ridaura Interferon, Rebif Imuran Retrovir, Apo-zidovudine Lioresal Levodopa Cogentin Interferon, recombinant Parlodel Sinemet Thorazine Leustatin Clozapine Clorazil N A Apo-benztropine Tacrine HCl Zidovudine, Lamivudine Entacapone Glatiramer acetate Dantrolene Dantrium N A N Eldepryl N A Aricept Levodopa N A Tensilon Selegiline Percocet Erythropoietin Flutamide N A Prolixin Eulexin Copaxone Ridaura Condition for which drug is most commonly used Chronic granulomatous disease Schizophrenia Parkinson's disease Mental health Parkinson's disease Narcotic Alcoholism Chronic anemia; renal failure Dementia Parkinson's disease Gold therapy rheumatoid arthritis Multiple sclerosis Multiple sclerosis HIV Multiple sclerosis Parkinson's disease Parkinson's disease Multiple sclerosis Parkinson's disease Parkinson's disease Mental health Luekemia, multiple sclerosis Mental health Mental health Pain control Parkinson's disease Dementia HIV Parkinson's disease Multiple sclerosis Multiple sclerosis Cerebral palsy, multiple sclerosis Pain control Pain control Dementia, parkinson's disease Pain control Dementia Parkinson's disease Pain control Myasthenia gravis Parkinson's disease Narcotic pain medication Renal failure, anemia of chronic disease If for recurrent prostate cancer Dementia Mental health Cancer Multiple sclerosis Rheumatoid arthritis and cogentin.
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Tions of glucose, a major stimulus of GIP secretion, were similar in OB and C adolescents. Nevertheless, our data do not suggest a causal role for GIP in the development of obesity or the hyperinsulinemia observed in OB subjects. Our results also provide new insight into the understanding of satiety in AN and OB subjects. The concepts of perceived hunger, desire to eat, and how much can I eat were consistently lower in the AN group than OB and C subjects over time. These results are in agreement with previous studies showing suppressed hunger in this condition, compared with normal-weight controls 5155 ; . Baseline hunger in OB was similar to controls, again consistent with previous data 56 ; . Interestingly, higher postprandial PYY concentrations but not absolute or relative ghrelin or GIP concentrations ; were associated with less hunger. This significant but 0.20 ; is consistent with modest temporal relationship r2 but does not prove the concept that PYY is involved in the physiology of appetite 2 ; . To test PYY, ghrelin, and GIP responses to caloric intake, we chose a mixed meal containing 55% carbohydrates, 25% protein, and 20% fat. The volume of the mixed meal was based on the subject's body weight, with a maximum of 360 ml, a quantity reached by most of the adolescents. As a consequence, the energy consumed by the OB subjects was only 14 and 3% greater than the energy consumed by AN and C subjects Table 1 ; . In addition, the source of carbohydrates in the liquid mixed meal corn syrup and sucrose ; was partially fructose. Although the presence of fructose is likely to have decreased the magnitude of glucose, insulin, and ghrelin responses to the meal, compared with a glucose-rich meal 57 ; , we feel that the composition of our mixed meal better reflects a real-life situation. Because the composition of the meal was the same in all three groups, the conclusions and cognex.
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In Vitro Expression of CD150 in PBMCs and CD4 + T cells of HBV Vaccine Non-Responder Health Care Workers HCWs ; Pati NT1, Sukriti1, Rajni Rani 2, Sarin SK1 1Department of Gastroenterology, G.B. Pant hospital, 2National Institute of Immunology, Aruna Asaf ali Marg, New Delhi, India
This screen displays up to 12 iterations of a drug's Base Line Price. Each iteration has a begin date and an end date. 1. BASE LINE PRICE: The Base Line Price is computed by averaging the AWP for all drugs with the same generic code number also known as the "Average Average Wholesale Prices" or "AAWP" ; . A minimum of three drugs with the generic code number is required to compute the Base Line Price. This average includes both brand name and generic drugs. The Base Line Price can be used for various pricing alternatives and colace.
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Rosai-Dorfman disease RDD ; is a rare disorder, often benign but with possible life-threatening prognosis. In most cases, specific treatment is not necessary; when required, the management of RDD is not codified to date, and various chemotherapies have been shown to be ineffective. Here, we report a patient with RDD who presented a dramatic and sustained response with cladribine. Analysis of the cytokine profile evolution shows a clear correlation between serum levels of TNF-alpha and IL-6 and disease activity. Our findings show the promising efficacy of cladribine and suggest that therapies targeting specifically cytokines might be useful in some cases of active RDD and clofarabine.
Letters in parentheses following drug names indicate: P ; for Primary, S ; for Secondary and T ; for Tertiary. 1. Classification of drugs for use at various levels of Health Services is as follows: P ; S ; T ; PRIMARY: For use at the Primary Health Care Level including Basic Health Units and Rural Health Centers. SECONDARY: For use at the Secondary Health Center Level i.e; hospitals. TERTIARY: For use at the specialized and sub-specialized levels for specific expertise diagnostic precision or special equipment required for proper use. II. Drugs subject to international controls under : 1 ; 2 ; Single Convention on Narcotic drugs 1961: Convention on Psychotropic Substances 1971; and Convention on Illicit Traffic in Narcotic Drugs and Psychotropic Substances 1988. In renal insufficiency, contraindicated or dosage adjustments necessary; To improve compliance; Special pharmacokinetic properties; Adverse effects diminish benefit risk ratio; Limited indications or narrow spectrum of activity; For epidural anaesthesia and colesevelam.
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